Acidic Oligosaccharide Sugar Chain, a Marine-Derived Acidic Oligosaccharide, Inhibits the Cytotoxicity and Aggregation of Amyloid Beta Protein
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概要
- 論文の詳細を見る
In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome O<sc>KAM</sc>, with amyloid beta protein (Aβ). We observed that AOSC inhibited the toxicity induced by Aβ in both primarily cortical cells and the SH-SY5Y cell line. We also observed that AOSC inhibited the apoptosis induced by Aβ in SH-SY5Y by reducing the elevated level of intracellular calcium concentration ([Ca2+]i) and suppressing the generation of reactive oxygen species. Surface plasmon resonance analysis demonstrated that AOSC had affinity for both freshly-dissolved Aβ and 48-h incubated Aβ. Furthermore, AOSC blocked the fibril formation of Aβ, which may be responsible for its anti-cytotoxic effects. Thus, our results indicate that AOSC might be a potentially therapeutic compound for Alzheimer’s disease.
- 社団法人 日本薬理学会の論文
- 2004-06-20
著者
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Li Jing
中華人民共和国
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Li Jing
Department Of Pharmacology Marine Drug And Food Institute Ocean University Of China
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GENG Meiyu
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China
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XIN Xianliang
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China
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DING Jian
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Xin Xianliang
Department Of Pharmacology Marine Drug & Food Institute Ocean University Of China
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Xin Xianliang
中華人民共和国
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Ding J
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Ding Jian
Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences
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Geng Meiyu
Department Of Pharmacology Marine Drug & Food Institute Ocean University Of China
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HU Jinfeng
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China
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WANG Jia
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China
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TANG Minke
Institute of Materia Media, Chinese Academy of Medical Sciences and Peking Union Medical College
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ZHANG Juntian
Institute of Materia Media, Chinese Academy of Medical Sciences and Peking Union Medical College
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ZHANG Xiao
Division of Molecular Neuropharmacology, Department of Neurotec, Karolinska Institute, Huddinge Univ
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Ding Jian
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Wang Jia
Department Of Microbiology Peking University Health Science Center
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Hu Jinfeng
Department Of Pharmacology Marine Drug And Food Institute Ocean University Of China
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Tang Minke
Institute Of Materia Media Chinese Academy Of Medical Sciences And Peking Union Medical College
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Zhang Juntian
Institute Of Materia Media Chinese Academy Of Medical Sciences And Peking Union Medical College
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Li J
Department Of Pharmacology Marine Drug And Food Institute Ocean University Of China
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Zhang X
Division Of Molecular Neuropharmacology Department Of Neurotec Karolinska Institute Huddinge Univers
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Li Jing
Department Of Agriculture Faculty Of Agriculture Kochi University
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Wang Jia
Department Of Pharmacology Marine Drug And Food Institute Ocean University Of China
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Geng Meiyu
Department of Marine Pharmacology, Marine Drug and Food Institute, Ocean University of China
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Wang Jia
Department of Immunology (Previous Second Department of Anatomy), Field of Infection and Immunity, Course of Health Research, Kagoshima University Graduate School of Medical and Dental Sciences
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