Studies of Marine Sulfated Polymannuroguluronate on Endothelial Cell Proliferation and Endothelial Immunity and Related Mechanisms
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概要
- 論文の詳細を見る
Anti-proliferation action and enhancement of endothelial cell immunity and related mechanisms by marine sulfated polymannuroguluronate (SPMG) were investigated in the present studies. Endothelial cell proliferation was evaluated by MTT assay. Intercellular adhesion molecule-1 (ICAM-1) expression was analyzed by flow cytometry. The interaction of SPMG with basic fibroblast growth factor (bFGF) was evaluated by surface plasmon resonance. Results showed that SPMG exhibited a significant inhibitory effect against proliferation in both normal human umbilical vein endothelial cells (HUVEC) and bFGF-treated HUVEC, the action of which was completely abrogated by bFGF antibody. SPMG exerted high affinity to bFGF in a multivalent pattern, characterized by one molecule SPMG binding to 3 – 4 molecules of bFGF. Moreover, SPMG enhanced ICAM-1 expression in HUVEC and prevented and restored bFGF-treated downregulation of ICAM-1 expression in HUVEC, the expression of which was not counteracted by bFGF antibody. In conclusion, this is the first report demonstrating that SPMG exerted an anti-proliferation effect dependent on the bFGF-regulated pathway and afforded upregulatory activity on ICAM-1 expression regardless of the involvement of bFGF.
- 社団法人 日本薬理学会の論文
- 2003-08-01
著者
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Li Jing
中華人民共和国
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Li Jing
Department Of Pharmacology Marine Drug And Food Institute Ocean University Of China
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GENG Meiyu
Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China
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DING Jian
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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WANG Lichun
Department of Marine Pharmacology, Marine Drug and Food Institute, Ocean University of China
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GUAN Huashi
Department of Marine Pharmacology, Marine Drug and Food Institute, Ocean University of China
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DING Jian
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Mat
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Ding J
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Ding Jian
Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences
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Ding Jian
Division Of Anti-tumor Pharmacology State Key Laboratory Of Drug Research Shanghai Institute Of Mate
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Geng Meiyu
Department Of Pharmacology Marine Drug & Food Institute Ocean University Of China
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Wang Lichun
Department Of Marine Pharmacology Marine Drug And Food Institute Ocean University Of China
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Guan Huashi
Department Of Marine Pharmacology Marine Drug And Food Institute Ocean University Of China
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Li J
Department Of Pharmacology Marine Drug And Food Institute Ocean University Of China
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Li Jing
Department Of Agriculture Faculty Of Agriculture Kochi University
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Geng Meiyu
Department of Marine Pharmacology, Marine Drug and Food Institute, Ocean University of China
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