PEGylated Recombinant Human Tumor Necrosis Factor Alpha : Pharmacokinetics and Anti-tumor Effects

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概要

• 論文の詳細を見る

• The aim of the present word was to investigate and assess the merit of PEGylated recombinant human tumor necrosis factor-α(rHuTNF-α)following our previous work. The rHuTNF-α was modified using activated polyethylene glycol(PEG), N-succinimidyl succinnate monomethoxy polyethylene glycol(SS-PEG). The pharmacokinetics and anti-tumor effect were investigated. The experimental results showed that PEGylated rHuTNF-α could obviously alter in vivo behavioral characteristics of rHuTNF-α. Among the synthesized PEG-rHuTNF-αs with different PEG molecules, PEG_<20000>-rHuTNF-α demonstrated the longest circulating half-life (24.8h)which was about 50 times longer than that of rHuTNF-α(28.8min). In addition, there was much more PEG_<20000>-rHuTNF-α distributed into tumor tissues than other PEG-rHuTNF-αs or rHuTNF-α with time, and PEG_<20000>-rHuTNF-α also showed the highest anti-tumor potency. These results indicated that PEG_<20000>-rHuTNF-α was a useful long circulating molecule with selective localization in tumor tissues and enhanced anti-tumor activity of rHuTNF-α.

• 公益社団法人日本薬学会の論文
• 2001-06-01

著者

• DING Jian

  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

• Zhang X‐y

  Shanghai Inst. Of Ceramics Chinese Acad. Of Sci. Shanghai Chn

• Gu Zhou-hui

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Zhou Zhao-hui

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Ding J

  Shanghai Institute Of Materia Medica Chinese Academy Of Sciences

• Ding Jian

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Zhou Jian-jun

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• ZHU Jian-Hua

  Department of Cardiology, Affiliated Hospital of Nantong University

• LI Ya-Ping

  Department of Pharmaceutics, School of Pharmacy, Fudan University

• PEI Yuan-Ying

  Department of Pharmaceutics, School of Pharmacy, Fudan University

• ZHANG Xian-Ying

  Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences

• GAO Xiu-Jian

  Department of Pharmaceutics, School of Pharmacy, Fudan University

• Li Ya-ping

  Department Of Pharmaceutics School Of Phamacy Fudan University:institute Of Materia Medica Shanghai

• Li Ya-ping

  Department Of Dermatology Faculty Of Medicine University Of Ryukyus

• Zhang Xian-ying

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Gao Xiu-jian

  Department Of Pharmaceutics School Of Phamacy Fudan University

• Zhu Jian-hua

  Department Of Cardiology Affiliated Hospital Of Nantong University

• Pei Yuan-ying

  Department Of Pharmaceutics School Of Phamacy Fudan University

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