Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor-α Carriers : Pharmacokinetics and Anti-tumor Effects

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概要

• 論文の詳細を見る

• The objective of this study was to inbestigate the pharmacokinetics and in vivo anti-tumor effect of recombinant human tumor necrosis factor-α(rHuTNF-α)encapsulated in poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate)(PEG-PHDCA)nanoparticles. Our experimental results showed that PEGPHDCA nanoparticle could extend the half-life of rHuTNF-α to 7.42h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-α to 7.42h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-α in tumor. Compared with PHDCA nanoparticles and free rHuTNF-α, PEG-PHDCA nanoparticles loaded with rHuTNF-α showed higher antitumor potency a the same dose, which might be related to its higher accumulation in tumor tissues and longer plasma circulation time. Therefore, PEG-PHDCA nanoprticles could be an effective carrier for rHuTNF-α.

• 公益社団法人日本薬学会の論文
• 2001-06-01

著者

• DING Jian

  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

• Zhang X‐y

  Shanghai Inst. Of Ceramics Chinese Acad. Of Sci. Shanghai Chn

• Gu Zhou-hui

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Zhou Zhao-hui

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Ding J

  Shanghai Institute Of Materia Medica Chinese Academy Of Sciences

• Ding Jian

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Zhou Jian-jun

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• ZHU Jian-Hua

  Department of Cardiology, Affiliated Hospital of Nantong University

• LI Ya-Ping

  Department of Pharmaceutics, School of Pharmacy, Fudan University

• PEI Yuan-Ying

  Department of Pharmaceutics, School of Pharmacy, Fudan University

• ZHANG Xian-Ying

  Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences

• GAO Xiu-Jian

  Department of Pharmaceutics, School of Pharmacy, Fudan University

• Li Ya-ping

  Department Of Pharmaceutics School Of Phamacy Fudan University:institute Of Materia Medica Shanghai

• Li Ya-ping

  Department Of Dermatology Faculty Of Medicine University Of Ryukyus

• Zhang Xian-ying

  Institute Of Materia Medica Shanghai Institute For Biological Science Chinese Academy Of Sciences

• Gao Xiu-jian

  Department Of Pharmaceutics School Of Phamacy Fudan University

• Zhu Jian-hua

  Department Of Cardiology Affiliated Hospital Of Nantong University

• Pei Yuan-ying

  Department Of Pharmaceutics School Of Phamacy Fudan University

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• PEGylated Recombinant Human Tumor Necrosis Factor Alpha : Pharmacokinetics and Anti-tumor Effects
• Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor-α Carriers : Pharmacokinetics and Anti-tumor Effects
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