Suppression of the Menadione-Induced Cytotoxicity toward Hepalclc7 Murine Hepatoma by Quinone Reductase Inducers
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概要
- 論文の詳細を見る
The obligatory two-electron reduction of quinones by quinone reductase (NAD(P)H:quinone oxidoreductase) competes with the one-electron reduction of quinones and protects cells against the cytotoxicity of quinones. We assessed the inhibitory effects of quercetin and curcumin against the menadione-induced cytotoxicity toward murine Hepa1c1c7 cells. tert-Butylhydroquinone, a positive control, induced the quinone reductase activity and suppressed the menadione-induced cytotoxicity. Both quercetin and curcumin induced the quinone reductase activity. While quercetin suppressed the menadione-induced cytotoxicity, curcumin showed no such suppressive effect.
- 社団法人 日本食品科学工学会の論文
- 2002-08-01
著者
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HASHIMOTO Kei
Department of Bioproductive Sciences, Utsunomiya University
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Hashimoto Kei
Department Of Bioproductive Sciences Utsunomiya University
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UDA Yasushi
Department of Bioproductive Sciences, Utsunomiya University
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Uda Yasushi
Department Of Agricultural Chemistry Utsunomiya University
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Uda Yasushi
Department Of Bioproductive Sciences Utsunomiya University
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NISHIKUBO Takeshi
Department of Bioproductive Sciences, Utsunomiya University
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KAWAMATA Hitomi
Department of Bioproductive Sciences, Utsunomiya University
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KAWAMATA Shinsuke
Department of Bioproductive Sciences, Utsunomiya University
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Kawamata Hitomi
Department Of Bioproductive Sciences Utsunomiya University
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Kawamata Shinsuke
Department Of Bioproductive Sciences Utsunomiya University
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Nishikubo Takeshi
Department Of Bioproductive Sciences Utsunomiya University
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HASHIMOTO Kei
Department of Applied Biological Chemistry, Utsunomiya University
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