Progressive Development of Pulmonary Hypertension Leading to Right Ventricular Hypertrophy Assessed by Echocardiography in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The present study aimed to evaluate the development of pulmonary hypertension by serial echocardiography, including measurements of pulmonary artery (PA) flow velocities, and correlate echocardiographic indices with pathological findings in rats administered monocrotaline (MCT). MCT (60 mg/kg body weight) or physiologic saline was administered to a total of 9 male Wistar rats at the age of 4 weeks (MCT group: n=4, control group: n=5, respectively). Echocardiography was performed serially until the age of 8 weeks. The ratio of right ventricular (RV) outflow tract dimensions to aortic dimensions increased progressively in the MCT group and became significantly greater than that of the control group after the age of 6 weeks. Peak PA velocity (Peak V) in the MCT group was significantly less than that of the control group at the ages of 7 and 8 weeks. The ratio of acceleration time to ejection time (AT/ET) in PA flow waveforms declined progressively and was significantly less than that of the control group after the age of 6 weeks. The ratio of RV weight to body weight (RVW/BW) in the MCT group was significantly greater than that of the control group. Both AT/ET ratio and Peak V were significantly inversely correlated with RVW/BW ratio. Furthermore, these echocardiographic findings were also significantly inversely correlated with the mean cross-sectional RV myocyte area. In conclusion, the progressive development of pulmonary hypertension leading to RV hypertrophy can be evaluated appropriately by echocardiography including PA flow Doppler indices in rats.

• 社団法人　日本実験動物学会の論文
• 2003-07-01

著者

• Yoshimori Yukie

  Department Of Nephrology Nagoya University Hospital

• Kondo Takaaki

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Kondo Takaaki

  Department Of Internal Medicine Division Of Cardio-vascular Medicine

• Kato Yosuke

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• NODA Akiko

  Nagoya University School of Health Sciences

• KOIKE Yasuo

  Nagoya University School of Health Sciences

• Yokota Mitsuhiro

  Department Of Clinical Pathophysiology Nagoya University Graduate School Of Medicine

• Kataoka Hiroki

  名古屋大学 医学系研究科循環器内科

• Kanda Hirofumi

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Nishizawa Takao

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• KANAZAWA Hiroaki

  School of Nursing, University of Shizuoka

• Kato Yuriko

  名古屋大学 医学系研究科生体生理解析学

• Yokota Mitsuhiro

  名古屋大学 医学系研究科生体生理解析学

• Kanazawa Hiroaki

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Noda Akiko

  School of Health Sciences, Nagoya University School of Medicine

• Koike Yasuo

  School of Health Sciences, Nagoya University School of Medicine

• Yokoi Toyoharu

  Nagoya University School of Health Sciences

• Iwase Mitsunori

  School Of Health Sciences Nagoya University

• Noda Akiko

  School Of Health Sciences

• KATO Yosuke

  School of Health Sciences, Nagoya University

• NISHIZAWA Takao

  Graduate School of Medicine, Nagoya University

• YOKOTA Mitsuhiro

  Graduate School of Medicine. Nagoya University

• KAWATA Natsuki

  School of Health Sciences, Nagoya University

• YOSHIMORI Yukie

  School of Health Sciences, Nagoya University

• HASHIMOTO Katsunori

  School of Health Sciences, Nagoya University

• YOKOI Toyoharu

  School of Health Sciences, Nagoya University

• TAKAGI Kenzo

  School of Health Sciences, Nagoya University

• NISHIMURA Masahiko

  Graduate School of Medicine, Nagoya University

• Kawata Natsuki

  School Of Health Sciences Nagoya University

• Nishimura M

  Graduate School Of Medicine Nagoya University

• Takagi Kenzo

  Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un

• Takagi Kenzo

  School Of Health Sciences Nagoya University

• Hashimoto Katsunori

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• Okada Mitsuhiro

  Department Of Genome Science School Of Dentistry Aichi-gakuin University

• Kanazawa Hiroaki

  School Of Nursing University Of Shizuoka

• Iwase Mitsunori

  Pathophysiological Laboratory Sciences Graduate School Of Medicine Nagoya University

• Kawaguchi Takeshi

  Kyoto University Center For Student Health

• Kanda Hirofumi

  Department Of Cardiology Nagoya University School Of Medicine

• Yokota Mitsuhiro

  Graduate School Of Medicine Nagoya University

• Kondo Takaaki

  Department Of Medical Technology Nagoya University School Of Health Science

関連論文

• Dietary Habits and Stomach Cancer Risk in the JACC Study
• OE-060 Large Blood Pressure Variability Superimposed on Sustained Hypertension Aggravates Cardiac Remodeling and Function via Angiotensin II-Mediated Inflammation(Hypertension, basic(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of
• Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARγ gene and colorectal cancer risk in Japanese
• PJ-772 The Present Condition of the Morning Hypertension Patients after JSH2004(Hypertension, clinical-12 (H) PJ134,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Serum Pepsinogen Values and Helicobacter pylori Status among Control Subjects of a Nested Case-Control Study in the JACC study
• Serum Levels of Insulin-like Growth Factor I, II, and Binding Protein 3, Transforming Growth Factor β-1, Soluble Fas Ligand and Superoxide Dismutase Activity in Stomach Cancer Cases and Their Controls in the JACC Study
• Green Tea and Stomach Cancer : A Short Review of Prospective Studies
• Mortality and Incidence Rates of Stomach Cancer in the JACC Study
• PJ-072 Estrogen Replacement Attenuates Vascular Inflammation and Prevents Myocardial Fibrosis and Diastolic Dysfunction in Ovariectomized Hypertensive Female Rats(PJ012,Calcium Handling, Cardiac Function (Basic) (M),Poster Session (Japanese),The 73rd Annu
• PJ-052 Simvastatin attenuates large blood pressure variability-induced aggravation of cardiac hypertrophy by inhibiting ERK and Rho A pathways(Cardiac hypertrophy, basic/clinical(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Ja
• PJ-831 Mesenchymal Stem Cell-transplantation Improves Endothelial Function in Monocrotaline-induced Pulmonary Hypertension Rats(Pulmonary circulation-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-639 Effect of Simvastatin and Telmiartan on Hypertensive Cardiac Remodeling by Exaggerated Blood Pressure Variability in Spontaneously Hypertensive Rats(Hypertension, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Association of a Polymorphism in the Ornithine Decarboxylase Gene with Whole Blood Polyamine Concentrations in a Non-smoking Healthy Population
• Association of Abdominal Circumference with Serum Nitric Oxide Concentration in Healthy Population
• Alcohol Consumption and Lung Cancer Mortality in Japanese Men : Results from Japan Collaborative Cohort (JACC) Study
• Genotype Announcement to Japanese Smokers Who Attended a Health Checkup Examination
• Lung Cancer Mortality and Serum Levels of Carotenoids, Retinol, Tocopherols, and Folic Acid in Men and Women : a Case-Control Study Nested in the JACC Study
• Updated Information on Risk Factors for Lung Cancer : Findings from the JACC Study
• Change of Medication to Candesartan is Effective for Patients with Early Morning Surge in Blood Pressure (from the ATOM Study) (Hypertension, Clinical 10 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Dietary Habits and Risk of Lung Cancer Death in a Large-scale Cohort Study (JACC Study) in Japan by Sex and Smoking Habit
• Decrease in Risk of Lung Cancer Death in Males after Smoking Cessation by Age at Quitting : Findings from the JACC Study
• Serum carotenoids and mortality from lung cancer : a case-control study nested in the Japan Collaborative Cohort (JACC) Study
• The Relationship between Smoking Habits and Serum Levels of 8-OHdG, Oxidized LDL Antibodies, Mn-SOD and Carotenoids in Rural Japanese Residents
• Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2
• Biological Monitoring of Pyrethroid Exposure of Pest Control Workers in Japan
• Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese
• Reduced risk of endometrial cancer from alcohol drinking in Japanese
• Serum Folate and Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Adjusted for Folate Intake
• Active Smoking, Passive Smoking, and Breast Cancer Risk : Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
• Dietary intakes of fat and fatty acids and risk of breast cancer : A prospective study in Japan
• Cigarette smoking and the risk of ovarian cancer in the Japanese population : Findings from the Japanese Collaborate Cohort study
• Impact of menstrual and reproductive factors on breast cancer risk in Japan : Results of the JACC study
• A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women : Findings from the JACC study
• A prospective study on the possible association between having children and colon cancer risk : Findings from the JACC Study
• LKB1 gene mutations in Japanese lung cancer patients
• Biological and clinical implications of EGFR mutations in lung cancer
• Influence of Life-related Factors and Participation in Health Examination on Mortality in a 4.5-year Follow-up of a Rural Cohort
• Association of menstrual and reproductive factors with pancreatic cancer risk in women : findings of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
• Relationships of Age at Menarche and Menopause, and Reproductive Year with Mortality from Cardiovascular Disease in Japanese Postmenopausal Women : The JACC Study
• No Association of the 5' Promoter Region Polymorphism of CYP17 with Breast Cancer Risk in Japan
• Knee Pain and its Associations with Age, Sex, Obesity, Occupation and Living Conditions in Rural Inhabitants of Japan
• Progressive Development of Pulmonary Hypertension Leading to Right Ventricular Hypertrophy Assessed by Echocardiography in Rats
• Effect of Green Tea Consumption on Endothelial Function and Circulating Endothelial Progenitor Cells in Chronic Smokers
• Body Surface Distribution of Changes in Activation-Recovery Intervals Before and After Catheter Ablation in Patients with Wolff-Parkinson-White Syndrome: Clinical Evidence for Ventricular "Electrical Remodeling" with Prolongation of Action Potential Durat
• Aortic Pressure Augmentation as a Marker of Cardiovascular Risk in Obstructive Sleep Apnea Syndrome
• Association of polymorphisms in the beta-2 and beta-3 adrenoceptor genes with risk of colorectal cancer in Japanese
• Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case-referent Study of a High-epidemic Area in Jiangsu Province, China
• Eating Fast Leads to Obesity : Findings Based on Self-administered Questionnaires among Middle-aged Japanese Men and Women
• OE-094 The Effect of Green Tea on Endothelial Dysfunction and Circulating Endothelial Progenitor Cells in Chronic Smoker(Atherosclerosis, clinical-1 (H) OE16,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
• Rationale, Design, and Profiles of the New Integrated Suburban Seniority Investigation (NISSIN) Project : A Study of an Age-Specific, Community-Based Cohort of Japanese Elderly
• Written Informed Consent for Participation in a Study and Reduction in Consent Rate
• Factors Related to Frequency of Engaging in Outside Activities among Elderly Persons Living an Independent Life at Home
• Birth Weight and Adult Hypertension : Cross-Sectional Study in a Japanese Workplace Population
• Serum Insulin-like Growth Factors, Insulin-like Growth Factor-biding Protein-3, and Risk of Lung Cancer Death : A Case-control Study Nested in the Japan Collaborative Cohort (JACC) Study
• Genetic factors involved in the development of Helicobacter pylori-related gastric cancer
• Simultaneous determination of urinary dialkylphosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry
• Determination of Salivary Theophylline Concentration by SLFIA Method and Pharmacokinetics in Saliva
• PJ-222 Exaggerated blood pressure variability aggravates hypertensive cardiac remodeling through the angiotensin II-mediated inflammatory changes(Hypertension, basic-3 (H) PJ37,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of th
• PJ-187 Mesenchymal Stem Cell-based Prostacyclin Synthase Gene Therapy Ameliorated Cardiovascular Remodeling and Improved Prognosis of Rats with Monocrotaline-induced Pulmonary Hypertension(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Pos
• FRS-032 Transient Reduction and Activation of Circulating Dendritic Cells in Patients with Acute Heart Failure(Clinical Heart Failure, Diagnosis and Treatment-2 (M) FRS7,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japan
• Mesencymal Stem Cell-based Prostacyclin Synthase Gene Therapy for Monocrotaline-induced Pulmonary Hypertension : The Rationale of Cell-Based Gene Delivery for the Lung(Gene Therapy 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
• SPRR1A is a gp130 Pathway and Stress Inducible Gene that Prevents Myocardial Injury during Ischemia(Cardiac Hypertrophy/Cardiomyopathy 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Pressure Overload-Induced Transient Oxidative Stress Mediates Perivascular Inflammation and Cardiac Fibrosis through Angiotensin II
• PJ-580 Oncostatin M, a Macrophage-Derived Cytokine, Upregulates Matrix Metalloproteinase-9 Through the MEK-ERK Pathway in Cultured Smooth Muscle Cells(Vasoactive Compound/Growth Factor/Cytokine 2 (H) : PJ97)(Poster Session (Japanese))
• OJ-506 Cytokine Signaling Suppressor SOCS1 is a Novel Therapeutic Target for Enterovirus-Induced Cardiac Injury(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese))
• OJ-303 Soluble Interferon-Gamma Receptor Gene Transfer into Skeletal Muscle Prevents Neointima Formation after Balloon Injury in Rats(Restenosis after Angioplasty, Basic/Clinical 2 (IHD) : OJ36)(Oral Presentation (Japanese))
• OE-326 Interferon-γ Is a New Therapeutic Target for Prevention of Atherosclerotic Lesion Formation(Gene Therapy 2 (IHD) : OE41)(Oral Presentation (English))
• FRS-097 Lacking the SOCS3 Gene in Macrophages Prevents the LPS-induced Endotoxin Shock in Mice(Inflammation and Cardiovascular Disease (IHD) : FRS12)(Featured Research Session (English))
• Pharmacokinetic Characteristics of a New Fluoroquinolone, Pazufloxacin, in Elderly Patients
• Stimulatory and Inhibitory Effects of Forskolin on Adenylate Cyclase in Rat Normal Hepatocytes and Hepatoma Cells
• COMPARATIVE STUDIES ON THE COMBINED CYTOTOXIC EFFECT OF FORSKOLIN WITH MITOMYCIN C AND RESPONSIVENESS TO FORSKOLIN IN RAT ASCITES HEPATOMA AH66 CELLS AND AH66F CELLS
• Repeated Prostacyclin Synthase Gene Transfer into a Remote Skeleton Muscle Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats
• Effect of hepatitis C virus infection on the risk of non-Hodgkin's lymphoma : A meta-analysis of epidemiological studies
• Effects of Social Relationships on Mortality among the Elderly in a Japanese Rural Area : An 88-month Follow-up Study
• Association of White Blood Cell Count and Clustered Components of Metabolic Syndrome in Japanese Men
• 58. Health care system in Vietnam : current situation and challenges
• Serum Phospholipid Transfer Protein Mass as a Possible Protective Factor for Coronary Heart Diseases
• Aldehyde Dehydrogenase 2 (ALDH2) Genotype Affects Rectal Cancer Susceptibility Due to Alcohol Consumption
• Plasma Fibrinogen Levels and Cardiovascular Risk Factors in Japanese Schoolchildren
• Sensitive Pupil Response of Early-Onset Alzheimer's Patients to a Dilute Mixture of Cholinergic Antagonist and α-Adrenergic Stimulant
• Ergonomic Evaluation of Working Posture of VDT Operation Using Personal Computer with Flat Panel Display
• Dietary Salt Intake and Blood Pressure among School children
• Impact of hospital volume on clinical outcomes of endoscopic biliary drainage for acute cholangitis based on the Japanese administrative database associated with the diagnosis procedure combination system
• Short- and Long-term Reliability of Information on Previous Illness and Family History as Compared with that on Smoking and Drinking Habits in Questionnaire Surveys
• Profiling of the Care Processes for Laryngeal Cancer with the Japanese Administrative Database
• Equivalent Clinical Outcomes of Bleeding Peptic Ulcers in Teaching and Non-Teaching Hospitals : Evidence for Standardization of Medical Care in Japan
• Gender and Age Differences in Lifestyle Factors Related to Hypertension in Middle-Aged Civil Service Employees
• Reproducibility and Validity of a Simple Checklist-type Questionnaire for Food Intake and Dietary Behavior
• Accommodative Load from Handheld Game Consoles in Kindergarten Children
• Evaluation of compliance with the Tokyo Guidelines for the management of acute cholangitis based on the Japanese administrative database associated with the Diagnosis Procedure Combination system
• Post-challenge hyperglycemia is a significant risk factor for the development of hepatocellular carcinoma in patients with chronic hepatitis C
• PJ-278 Distinctive Characters of Endothelial Progenitor Cells in Human Umbilical Cord Blood(Regeneration (angionenesis/myocardial regeneration)-8 (M) PJ47,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
• The Relationship between Smoking Habits and Serum Levels of 8-OHdG, Oxidized LDL Antibodies, Mn-SOD and Carotenoids in Rural Japanese Residents
• A descriptive study evaluating the circumstances of medical treatment for acute pancreatitis before publication of the new JPN guidelines based on the Japanese administrative database associated with the Diagnosis Procedure Combination system
• Disability-Adjusted Life Years (DALY) for Cancer in Japan in 2000
• Seropositivity for Anti-HCV Core Antigen is Independently Associated With Increased All-Cause, Cardiovascular, and Liver Disease-Related Mortality in Hemodialysis Patients
• Body Mass Index and Mortality From All Causes and Major Causes in Japanese : Results of a Pooled Analysis of 7 Large-Scale Cohort Studies
• Weight Gain During Adulthood and Body Weight at Age 20 Are Associated With the Risk of Endometrial Cancer in Japanese Women
• Comparison of axial force and cell width of self-expandable metallic stents : which type of stent is better suited for hilar biliary strictures?
• Smoking and Smoking Cessation in Relation to All-Cause Mortality and Cardiovascular Events in 25,464 Healthy Male Japanese Workers

もっと見る 閉じる

スポンサーリンク