Comparative Study of the Effects of Indomethacin and NS-398, a Selective Cyclooxygenase 2 Inhibitor, on Duodenal Bicarbonate Secretion Induced by Luminal Acidification in Rats
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概要
- 論文の詳細を見る
To clarify the mechanisms of duodenal ulcerogenic activity of non-steroidal anti-inflammatory drugs (NSAIDs), the effects of indomethacin (IND) on acid-stimulated duodenal bicarbonate secretion and histamine-induced duodenal ulcerogenic responses were studied in comparison with NS-398, a selective cyclooxygenase (COX)-2 inhibitor, in rats. IND (1 and 5 mg/kg, s.c.) significantly decreased duodenal bicarbonate secretion and potentiated duodenal lesion in a dose-dependent manner. On the other hand, NS-398 had no effect on these parameters. These findings suggest that duodenal ulcerogenicity of IND in the presence of histamine is mainly due to the inhibitory action on acid-stimulated bicarbonate secretion mediated by COX-1, but not by COX-2.
- 社団法人 日本薬理学会の論文
- 1997-10-01
著者
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Saito Takako
Research And Development Laboratories Maruho Co. Ltd.
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Iwata Kazumi
Research And Development Laboratories Maruho Co. Ltd.
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Naruse Taeko
Department Of Molecular Life Science Tokai University School Of Medicine
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Takase H
Research And Development Laboratories Maruho Co. Ltd
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Saito T
Research And Development Laboratories Maruho Co. Ltd.
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Naruse T
Research And Development Laboratories Maruho Co. Ltd.
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MURAKAMI Naofumi
Research and Development Laboratories, Maruho Co., Ltd
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TAKASE Hiroshi
Research and Development Laboratories, Maruho Co., Ltd
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NARUSE Tomohiro
Research and Development Laboratories, Maruho Co., Ltd
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Murakami Naofumi
Research And Development Laboratories Maruho Co. Ltd.
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Murakami Naofumi
Research & Development Laboratories Maruho Co. Ltd.
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Naruse Tomohiro
Research & Development Laboratories Maruho Co. Ltd.
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