Pharmacological Blockade of I[Ks] Destabilizes Spiral-Wave Reentry Under β-Adrenergic Stimulation in Favor of Its Early Termination
スポンサーリンク
概要
著者
-
Honjou Haruo
名古屋大学 循環器内科学
-
Honjou Haruo
Department Of Humoral Regulation Research Institute Of Environmental Medicine Nagoya University
-
本荘 晴朗
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
関連論文
- 光学マッピングによる不整脈研究--スパイラルリエントリーのダイナミクス解析と制御 (第1土曜特集 ここまで進んだ 不整脈研究の最新動向) -- (不整脈研究の最先端)
- 循環器診療における検査・治療機器の使用、保守管理に関するガイドライン
- 1107 心筋細胞活動電位数値計算モデルを用いたKCNE1/KCNQ1発現量比と心電図QT間隔の関連性に関する検討(S02-2 循環器系・呼吸器系の生体機能モデリング(2),S02 循環器系・呼吸器系の生体機能モデリング)
- 心筋細胞活動電位数値計算モデルを用いた動物種によるI_ブロッカーに対する感受性の違いに関する検証
- 9) アルドステロンの心筋細胞ギャップ結合リモデリングへの影響(第91回日本循環器学会中国地方会)
- 心不全発現過程におけるギャップ結合リモデリングについて(4.心不全と不整脈,第71回日本循環器学会学術集会)
- 心房細動治療(薬物)ガイドライン(2008年改訂版)(ダイジェスト版,循環器病の診断と治療に関するガイドライン(2006-2007年度合同研究班報告))
- 心房細動治療(薬物)ガイドライン(2008年改訂版)(循環器病の診断と治療に関するガイドライン(2006-2007年度合同研究班報告))
- 心房細動治療(薬物)ガイドライン(2008年改訂版)
- QT延長症候群(先天性・二次性)とBrugada症候群の診療に関するガイドライン(ダイジェスト版,循環器病の診断と治療に関するガイドライン(2005-2006年度合同研究班報告))
- QT延長症候群(先天性・二次性)とBrugada症候群の診療に関するガイドライン(循環器病の診断と治療に関するガイドライン(2005-2006年度合同研究班報告))
- 発作性心房細動から持続性心房細動に移行する際の心拍数の推移
- 51) 持続性心房細動の細動周期に及ぼすベプリジルとI群薬併用の効果(第131回日本循環器学会東海地方会)
- 43) 冠動脈-右房瘻を合併した右房起源非通常型心房粗動の一例(第131回日本循環器学会東海地方会)
- 130) 持続性心房細動症例における心房内細動周期と肺静脈隔離後の細動誘発性に及ぼすベプリジルの効果(日本循環器学会第130回東海・第115回北陸合同地方会)
- 129) Verapamilは発作性心房細動を増悪させる : 肺静脈および心房内細動周期に及ぼす影響(日本循環器学会第130回東海・第115回北陸合同地方会)
- 124) アブレーションが奏功した心房細動誘発性重症心不全の一例(日本循環器学会第130回東海・第115回北陸合同地方会)
- 39) 心室再同期療法における心房中隔ペーシングの効果(日本循環器学会第130回東海・第115回北陸合同地方会)
- 119)左室機能に及ぼす右室2点ペーシングの影響(第129回日本循環器学会東海地方会)
- 110)心室温度がスパイラルリエントリーのダイナミクスに及ぼす影響 : 活動電位光学マッピングによる解析(日本循環器学会第126回東海・第111回北陸合同地方会)
- 院外心肺停止患者における電気的除細動抵抗性の心室頻拍・心室細動に対するリドカインとIII群抗不整脈薬の効果 : 臨床例と基礎的実験の検討から
- 81)急性圧負荷が心房興奮伝播に及ぼす影響 : 家兎潅流心圧負荷モデルを用いた検討(第127回日本循環器学会東海地方会)
- 薬物による心室スパイラル・リエントリーの制御 : K^+チャネル遮断薬の有用性と限界
- OE-425 Changes of Adhesion Junctions Precede the Gap Junction Remodeling during the Development of Heart Failure(OE72,Arrhythmia, Mechanism (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- TRPC伸展誘発イオンチャネルと心房細動
- 1)心室スパイラル・リエントリーに対するベプリジルの作用 : 活動電位光学マッピングを用いた実験的検討(第129回日本循環器学会東海地方会)
- 146)心房拡大に伴う心房細動発生基質の成立とベプリジルの坑細動効果について(日本循環器学会第128回東海・第113回北陸合同地方会)
- 119) ウサギ摘出灌流心の電気生理学的性質に対するIKr・IKsチャネル阻害と交感神経β受容体刺激の相互作用(第131回日本循環器学会東海地方会)
- 113) 骨格筋芽細胞移植による心臓再生治療 : in-vitroモデルを用いた催不整脈性の検討(第131回日本循環器学会東海地方会)
- 145)坑不整脈薬ソタロールのHERGチャネル結合の分子機序(日本循環器学会第128回東海・第113回北陸合同地方会)
- 82)ニフェカラントのHERGチャンネルに対するagonist作用について(第127回日本循環器学会東海地方会)
- Effects of Aldosterone on Cx43 Gap Junction Expression in Neonatal Rat Cultured Cardiomyocytes
- スパイラルリエントリへの点通電刺激における仮想電極現象の解析
- Optical mapping による spiral wave の解析
- スパイラル・リエントリーのダイナミクスとその制御 (第9回九州重症不整脈研究会)
- PE-010 Moderate Hypothermia Destabilized Spiral Waves without Widening Excitable Gap in Favor of Self-termination of Ventricular Tachycardia/Fibrillation(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese C
- Modulation of Spiral Wave Reentry by K^+ Channel Blockade(Mechanisms and Future Challenge)
- PE-017 Moderate Hypothermia Causes Destabilization of Rotors without Wavelength Shortening in Favor of VT/VF Self-Termination(Arrhythmia, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-149 Pacing-Induced Heart Failure in Rabbits Accelerates Subepicardial Ventricular Repolarization in Favor of Mother Rotor-Type Ventricular Fibrillation(Arrhythmia, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-238 Mechanisms of Global and Regional Cooling-Assisted Defibrillation in a Bidomain Ventricular Model(Arrhythmia, basic-1 (A) OE40,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Acute Amiodarone Suppresses Action Potential Alternans in the Two-dimensional Ventricular Myocardium of Rabbit Hearts(Arrhythmia, Basic 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Action Potential Dynamics of Spiral-type Reentry in 2-Dimensional Anisotropic Layer of Ventricular Muscle : Optical Mapping Analysis Using High-fidelity CMOS Camera(Arrhythmia, Basic 3 (A), The 69th Annual Scientific Meeting of the Japanese Circulation So
- 1 Gap Junction Remodeling is an Important Arrhythmogenic Substrate during the Development of Heart Failure(Heart Failure and Arrhythmia, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Gap Junction Remodeling is an Arrhythmogenic Substrate during the Development of Heart Failure in Cardiomyopathic Hamster(Arrhythmia, Basic 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Right Ventricular Septal Pacing Preserves Long-Term Left Ventricular Function Via Minimizing Pacing-Induced Left Ventricular Dyssynchrony in Patients With Normal Baseline QRS Duration
- Action Potential Characteristics in the Sinus Venosa of Patients With and Without Atrial Flutter
- PJ-556 Intercellular Uncoupling Stabilizes Spiral-wave Reentry in Favor of its Persistence(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-428 β-Adrenergic Effects on the Dynamics of Spiral Wave Reentry in Langendorff-Perfused Rabbit Hearts(OE72,Arrhythmia, Mechanism (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-054 Bepridil Destabilizes Spiral-Wave Reentry in Favor of Its Early Termination through Tremendous Drift of Rotation Center(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeti
- Internalization and Dephosphorylation of Connexin43 in Hypertrophied Right Ventricles of Rats With Pulmonary Hypertension
- Bepridil Facilitates Early Termination of Spiral-Wave Reentry in Two-Dimensional Cardiac Muscle Through an Increase of Intercellular Electrical Coupling
- 1004 光学計測による心筋組織通電時の空間的膜電位分布と仮想電極分極現象誘発興奮伝搬の解析(GS13:生体計測)
- Opposing Effects of Bepridil on Ventricular Repolarization in Humans : Inhomogeneous Prolongation of the Action Potential Duration vs Flattening of Its Restitution Kinetics
- PJ-431 Single Carbon-ion Irradiation to Canine Heart in Myocardial Infarction Improves the Conduction Delay in the Left Ventricle over One-year(PJ073,Arrhythmia, Others (Basic) 1 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japa
- PE-035 Association of Renal Artery Stenosis with Anemia and Heart-type Fatty Acid Binding Protein(PE006,Kidney/Renal Circulation/CKD 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- DPE-017 Verapamil Remodels Paroxysmal Atrial Fibrillation via Acceleration of Fibrillation Frequency and Elimination of Pulmonary Vein-to-Left Atrial Frequency Gradient(DPE03,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) (A),Digital Poster Sessi
- DPE-016 Possible Mechanism for Defibrillation of Long-Lasting Persistent Atrial Fibrillation with Bepridil(DPE03,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) (A),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanes
- OJ-157 MK Gene Transfer Causes Amelioration of Cardiac Remodeling after Myocardial Infarction through Enhancements of Neovascularization and Cell Survival(OJ27,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (Japanes
- OE-427 Ventricular Fibrillation in CHF is Characterized by the Existence of Multiple High-frequency Rotating Activities(OE72,Arrhythmia, Mechanism (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-424 Patterned Cell Alignment Using Magnetite Nanoparticles to Prevent Arrhythmogenicity of Skeletal Myoblast Transplantation(OE72,Arrhythmia, Mechanism (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
- OE-284 Bachmann's Bundle Pacing Ameliorates Efficacy of Cardiac Resynchronization Therapy via Achieving Atrial Mechanical Synchronization(OE48,CRT (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-470 The effects of Body Weight Change, Age and Percent Body Fat in 5 Years on Morbidity of Life-style related diseases(Preventive medicine/Epidemiology/Education(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulat
- OE-338 Order of the Onset of Diabetes Mellitus, Hypertension, and Dyslipidemia in Japanese Males(Diabetes/Obesity/Metabolic syndrome(02)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-089 Long Term (5 years) Follow-up of the Effects of Lipid Parameters and Fasting Plasma Glucose Levels by Weigh Change(New Insights into Metabolic Syndrome(01)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation
- 第25回日本心電学会学術集会
- OE-269 Bepridil Reduces Dilatation-induced Vulnerability to Atrial Fibrillation in Rabbit Hearts through Prevention of Refractory Period Shortening and Heterogeneous Intraatrial Conduction(Arrhythmia, basic-2, The 71st Annual Scientific Meeting of the Jap
- Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
- FRS-051 Role of Ca^-activated Signals and Ca^-handling Protein Phosphorylation Abnormalities in Electrical Storm(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of T
- 心血管イベントとミッドカイン (AYUMI ミッドカイン--機能解析から臨床応用へ) -- (ミッドカインの臨床応用)
- FRS-031 Midkine Prevents Cardiac Remodeling in Rabbit Congestive Heart Failure through Its Anti-apoptotic Effect(FRS7,Challenging Approaches to Heart Failure Treatment (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japan
- PJ-204 Subepicardial Ventricular Muscle in Tachycardia-induced Heart Failure Shows Prominent Rate-dependent Shortening of Action Potential Duration and Reduction of I_(Arrhythmia, basic(05)(A),Poster Session(Japanese),The 72nd Annual Scientific Meet
- OJ-070 Combined Effects of INa and ICa, Blockade on Spiral Wave Reentry in Perfused 2-dimensional Layer of Rabbit Ventricular Myocardium(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- シンポジウム 第61回福岡不整脈同好会 心房細動の電気生理学
- PJ-160 Comparative Analysis of Dual Actions of Nifekalant on I_(PJ027,Arrhythmia, Others (Clinical/Pathophysiology) 2 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Altered expression of connexin43 contributes to the arrhythmogenic substrate during the development of heart failure in cardiomyopathic hamster
- PE-131 IKr Blocker Induces Interventricular APD Dispersion and Leads to Spiral Wave-type Polymorphic VT, But IKs Blocker Does Not in Rabbits(Arrhythmia, basic-3 (A) PE22,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japane
- Profiles of mRNA and Protein Expressions for Ion Channels and Connexins in the Pulmonary Vein of Rabbit Hearts (Arrhythmia, Basic 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-015 Drug-Trapping May Determine the Potency of hERG Block(Arrhythmia, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myocardial infarction
- Mechanisms of destabilization and early termination of spiral-wave reentry in the ventricle by a class III antiarrhythmic agent, nifekalant
- Upregulation of KCNE1 Induces QT Interval Prolongation in Patients With Chronic Heart Failure
- 心房細動 up to date : 1)細動基質としての心房筋/肺静脈の電気生理とその修飾
- PE-518 Anemia and Low T3 Syndrome Reflect the Presence of Cardiac Symptoms in Hypertensive Heart Disease(Hypertension, clinical-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-340 Cystatin C reflects the Onset of Cardiac Symptoms in Hypertensive Heart Failure with Preserved Systolic Function(Heart failure, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 心筋の小胞体機能と正常・異常自動能
- Longitudinal analysis of the depressive effects of intravenous amiodarone on depolarization and repolarization : A case report
- 座談会 不整脈Up to Date
- ベプリジルは活動電位持続時間を延長し、細胞間電気結合を増大することでスパイラル・リエントリーを不安定化させる
- 心室頻拍・心室細動に対するアミオダロンの使い方 : 静注薬を中心として
- Short-term Effects of Amiodarone on the Electrophysiological Characteristics Differ from Long-term Effects in Rabbit Atrial Myocytes(Arrhythmia, Pharmacological Therapy 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-332 Acute Effects of Amiodarone on the Electrophysiological Characteristics of Rabbit Atrial Myocytes(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
- PE-408 Increased Heart-type Fatty Acid Binding Protein Levels Reflect Cardiac Symptoms in Hypertensive Heart Diseases(Hypertension, clinical-6 (H) PE68,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
- PE-314 Additive Predictive Value of von Willebrand Factor for the Prognosis of Hypertensive Patients with Aortic Regurgitation(Vascular heart disease/Pericarditis/Cardiac tumor-2 (M) PE53,Poster Session (English),The 70th Anniversary Annual Scientific Mee
- Low Thyroid Function (Low T3) Predicts the Prognosis of Patients with Hypertensive Heart Failure(Heart Failure, Clinical 11 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-261 Heart-type Fatty Acid Binding Protein Predicts the Progression of Left Ventricular Hypertrophy in Aortic-valve Stenosis(Valvular Heart Disease/Pericarditis/Cardiac Tumor 1 (M) : PE45)(Poster Session (English))
- Prognostic Value of Heart Type Fatty Acid-Binding Protein (H-FABP) in Patients with Aortic Valve Stenosis
- Bepridil Facilitates Early Termination of Spiral-Wave Reentry in Two-Dimensional Cardiac Muscle Through an Increase of Intercellular Electrical Coupling
- Pharmacological Blockade of I[Ks] Destabilizes Spiral-Wave Reentry Under β-Adrenergic Stimulation in Favor of Its Early Termination
- Pharmacological Blockade of I_ Destabilizes Spiral-Wave Reentry Under β-Adrenergic Stimulation in Favor of Its Early Termination
- 7F16 心筋興奮伝播のリアルタイム画像処理による最適除細動刺激システム(OS06 心臓疾患への工学技術の多面的アプローチ)