1107 心筋細胞活動電位数値計算モデルを用いたKCNE1/KCNQ1発現量比と心電図QT間隔の関連性に関する検討(S02-2 循環器系・呼吸器系の生体機能モデリング(2),S02 循環器系・呼吸器系の生体機能モデリング)

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In heart failure, QT interval and action potential duration (APD) is prolonged and I_<Ks>, a slow component of delayed rectifier potassium current, decreases. We have reported that the KCNE1 gene, coding I_<Ks> channel, increases and QT interval is prolonged in patients with heart failure. In this study, we construct a cardiac membrane action potential simulation model and pseudo-ECG model based on the oocytes expression experiments to investigate the relationship between the increase of KCNE1, APD and QT interval. In modeling process, increase of KCNE1 expression level leaded increase of maximum I_<Ks>, conductance, shift of activation curve to depolarization side and increase of time constants of I_<Ks>, channel. In simulations, APD and QT interval was prolonged, and I_<Ks> was suppressed by increase of co-injected amount of KCNE1. Therefore, increase of KCNE1 expression level may contribute to APD and QT interval prolongation in heart failure.
2007-09-07