Acoustic Response of Microbubbles Derived from Phase-Change Nanodroplet
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概要
- 論文の詳細を見る
An in vitro feasibility test for a novel ultrasound therapy using a type of superheated perfluorocarbon droplet, phase-change nanodroplet (PCND), was performed in gel phantoms with the goal of high selectivity and low invasiveness. Measurements of broadband signal emission revealed that a triggering ultrasound pulse (peak negative pressure of 2.4 MPa) reduces the pressure threshold for cavitation induced by a subsequent ultrasound exposure at an order of magnitude from 2.4 to 0.2 MPa. The maximum allowed interval between the two ultrasound exposures for inducing cavitation with 100- and 1,000-cycle triggering ultrasound was about 100 and 500 ms, respectively. The echo signal increases induced by the triggering ultrasound with 100- and 1000-cycles were enhanced and suppressed by the subsequent ultrasound exposure, respectively. This different behavior seemed to be due to the presence of enlarged free bubbles, which should be avoided for the localization of therapeutic effects.
- 2010-07-25
著者
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Kawabata Ken-ichi
Central Research Lab. Hitachi Ltd.
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Azuma Takashi
Central Research Laboratory Hitachi Ltd.
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Asami Rei
Central Research Laboratory, Hitachi Ltd., 1-280 Higashi-Koigakubo, Kokubunji, Tokyo 185-8601, Japan
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Umemura Shin-ichiro
Graduate School of Bioengineering, Tohoku University, 6-6 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
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Asami Rei
Central Research Laboratory, Hitachi, Ltd., 1-280 Higashi-Koigakubo, Kokubunji, Tokyo 185-8601, Japan
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