Verification of Ultrasonic Thrombolysis Effect by in Vitro Experiments
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概要
- 論文の詳細を見る
The tissue plasminogen activator (t-PA) has been approved as a thrombolytic agent for treating cerebral thrombosis. It is reported that recanalization occurs earlier in a hyperacute ischemic stroke when both t-PA and transcranial ultrasonication are applied than when t-PA alone is applied. We have developed a therapy-and-diagnostics (T/D) compound transcranial ultrasonic thrombolytic system. To minimize adverse mechanical and thermal biological effects, the frequency of the therapeutic ultrasound (US) beam is selected to be 500 kHz. The diagnostic US beam at 2 MHz is used for monitoring the recanalization. We confirmed the effect of this system using two types of experiment. One determined the recanalization rate and dissolution time of the simulated thrombotic vascular occlusion at narrowed vessels and the other determined the weight decrease of the clot, and both involved exposure to t-PA solution with and without ultrasonication. As a result, the recanalization rate is higher in the $\text{US}+\text{t-PA}$ (92.3%) than in the t-PA-only (64.1%). The decrease rate is also higher in the $\text{US}+\text{t-PA}$ (25.4%) than in the t-PA-only (15.1%).
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2006-05-30
著者
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Ogihara Makoto
Research And Development Center Hitachi Medical Corporation
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Furuhata Hiroshi
Medical Engineering Laboratory Research Center For Medical Science Jikei University School Of Medici
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Azuma Takashi
Central Research Laboratory Hitachi Ltd.
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Kubota Jun
Research And Development Center Hitachi Medical Corporation
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Ogihara Makoto
Research and Development Center, Hitachi Medical Corporation, Kashiwa, Chiba 277-0804, Japan
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Umemura Shin-ichiro
Health Sciences Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan
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Ando Kazumi
Department of Anesthesiology, Jikei Medical School of Medicine, Tokyo 105-8461, Japan
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Tanihuji Yasumasa
Department of Anesthesiology, Jikei Medical School of Medicine, Tokyo 105-8461, Japan
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Furuhata Hiroshi
Medical Engineering Laboratory, Jikei University School of Medicine, Tokyo 105-8461, Japan
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