Phase Change Nanodroplets and Microbubbles Generated from Them as Sources of Chemically Active Cavitation
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概要
- 論文の詳細を見る
Aiming at a multidisciplinary tumor treatment with thermal and chemical mechanisms, the effect of phase change nanodroplets (PCNDs) on inducing reactive chemical species through cavitation was evaluated <i>in vitro</i>. By using the reaction yield of the oxidation of iodide ions to tri-iodide ions as a measure, the effect of PCNDs and PCND-derived microbubbles were investigated. The presence of PCNDs reduced the intensity threshold for chemical reaction by at least 40%. Furthermore, the threshold with PCND-derived microbubbles was 5 times lower than that with PCNDs alone. The interval of exposing the phase change trigger, which is used to generate microbubbles from PCNDs, was found to be shorter than 0.01 s for efficient induction of a chemical reaction. The reaction yields were independent of PCND concentration, thus PCND-derived microbubbles are not considered to work directly in the generation of chemical species undergoing the reaction.
- 2011-07-25
著者
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Kawabata Ken-ichi
Central Research Lab. Hitachi Ltd.
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Maruoka Takashi
Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo 185-8601, Japan
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Asami Rei
Central Research Laboratory, Hitachi Ltd., 1-280 Higashi-Koigakubo, Kokubunji, Tokyo 185-8601, Japan
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Asami Rei
Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo 185-8601, Japan
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Umemura Shin-ichiro
Graduate School of Bioengineering, Tohoku University, Sendai 980-8579, Japan
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Umemura Shin-ichiro
Graduate School of Bioengineering, Tohoku University, 6-6 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
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