Analysis of Temperature Rise Induced by High-Intensity Focused Ultrasound in Tissue-Mimicking Gel Considering Cavitation Bubbles

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概要

• 論文の詳細を見る

• High-intensity focused ultrasound (HIFU) causes a selective temperature rise in tissue and is used as a noninvasive method for tumor treatment. However, there is a problem in that it typically takes several hours to treat a large tumor. The development of a highly efficient method is required to shorten the treatment time. It is known that cavitation bubbles generated by HIFU enhance HIFU heating. In this study, the enhancement of the heating effect by cavitation was estimated in a numerical simulation solving a bio-heat transfer equation (BHTE) by increasing the absorption coefficients in and out of the volume of cavitation bubbles. The absorption coefficients were obtained by a curve fitting the temperature rise near the focal point between experiment and simulation. The results show that cavitation bubbles caused the increase in ultrasonic absorption not only in but also near the volume of cavitation bubbles.

• 2013-07-25

著者

• Umemura Shin-ichiro

  Graduate School of Bioengineering, Tohoku University, 6-6 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan

• Yoshizawa Shin

  Graduate School of Engineering, Tohoku University, Sendai 980-5879, Japan

• Asai Ayumu

  Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan

• Okano Hiroki

  Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan

関連論文

• Analysis of High-Intensity Focused Ultrasound Source Using Time Reversal: Effect of Lamb-Like Waves
• Ultrasonic coagulation of large tissue region by generating multiple cavitation clouds in direction perpendicular to ultrasound propagation (Special issue: Ultrasonic electronics)
• Phase Change Nanodroplets and Microbubbles Generated from Them as Sources of Chemically Active Cavitation
• Quantitative Measurement of Focused Ultrasound Pressure Field Using Subtraction Shadowgraph
• Breathing-Mode Ceramic Element for Therapeutic Array Transducer
• Staircase-Voltage Metal–Oxide–Semiconductor Field-Effect Transistor Driver Circuit for Therapeutic Ultrasound
• Sustaining Microbubbles Derived from Phase Change Nanodroplet by Low-Amplitude Ultrasound Exposure
• Acoustic Response of Microbubbles Derived from Phase-Change Nanodroplet
• Therapeutic Array Transducer Element Using Coresonance between Hemispherical Piezoceramic Shell and Water Sphere: Effect of Load Masses of Support and Electric Contact
• Enhancement of Localized Heating by Ultrasonically Induced Cavitation in High Intensity Focused Ultrasound Treatment
• Coagulation of Large Regions by Creating Multiple Cavitation Clouds for High Intensity Focused Ultrasound Treatment
• Efficient Generation of Cavitation Bubbles in Gel Phantom by Ultrasound Exposure with Negative-Followed by Positive-Peak-Pressure-Emphasized Waves
• Large Volume Coagulation Utilizing Multiple Cavitation Clouds Generated by Array Transducer Driven by 32 Channel Drive Circuits
• Optical Phase Contrast Mapping of Highly Focused Ultrasonic Fields
• Analysis of Temperature Rise Induced by High-Intensity Focused Ultrasound in Tissue-Mimicking Gel Considering Cavitation Bubbles
• Enhancement of Focused Ultrasound Treatment by Acoustically Generated Microbubbles
• Analysis of Temperature Rise Induced by High-Intensity Focused Ultrasound in Tissue-Mimicking Gel Considering Cavitation Bubbles

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