Theoretical Prediction and Atomic Force Microscope Observations of the Protein Nanotube Consisting of Homo-l-Amino Acid Penta-Peptide Nanorings
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概要
- 論文の詳細を見る
An unusual penta-peptide nanotube was synthesized by a solid-phase method using Fmoc chemistry. This nanotube consists of the natural homo-l-amino acid sequence (cyclo[-(l-Gln)5]), which is different from the already-known dl-peptide nanotubes having an even number of residues. We also observed the morphology by atomic force microscope (AFM) and found meandering tubular structures on the substrate. This result is consistent with our ab initio energy calculations, which show that the penta-peptide nanorings stabilize by breaking the C5 symmetry and stack themselves to form a meandering nanotube through the inter-ring hydrogen bonds.
- Publication Office, Japanese Journal of Applied Physics, Faculty of Science, University of Tokyoの論文
- 2003-02-15
著者
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Mihara Hisakazu
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Nagai Yukiko
Department Of Materials Science And Engineering Waseda University
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Azehara Hiroaki
Joint Research Center For Atom Technology (jrcat)-nanotechnology Research Institute National Institu
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Obataya Ikuo
Department Of Bioengineering Faculty Of Bioscience And Biotechnology Tokyo Institute Of Technology
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Okamoto Hajime
Department Of Materials Science And Engineering Waseda University
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Nakanishi Tsutomu
Department Of Materials Sciences Waseda Universit
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Mizutani Wataru
Joint Research Center for Atom Technology (JRCAT)–National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 4, Higashi 1-1-1, Tsukuba, Ibaraki 305-8562, Japan
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Mizutani Wataru
Joint Research Center for Atom Technology (JRCAT)-Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562, Japan
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Takeda Kyozaburo
Department of Materials Science and Engineering, Waseda University, Tokyo 169-8555, Japan
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Takeda Kyozaburo
Department of Electrical Engineering and Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan
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Mihara Hisakazu
Department of Bioengineering, Tokyo Institute of Technology, Yokohama 226-8501, Japan
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Nagai Yukiko
Department of Materials Science and Engineering, Waseda University, Tokyo 169-8555, Japan
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Azehara Hiroaki
Joint Research Center for Atom Technology (JRCAT)-Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562, Japan
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Obataya Ikuo
Department of Bioengineering, Tokyo Institute of Technology, Yokohama 226-8501, Japan
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Nakanishi Tsutomu
Department of Materials Science and Engineering, Waseda University, Tokyo 169-8555, Japan
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