Heterogeneous and abnormal localization of desmosomal proteins in oral intraepithelial neoplasms
スポンサーリンク
概要
- 論文の詳細を見る
To study the relationship between the biological and morphological characteristics of oral intraepithelial neoplasms (OINs), we examined the localization of desmosome-related proteins. Twenty-seven cases of OIN3 were tentatively classified as basaloid (14 cases) or differentiated (13 cases), and the latter were further subdivided into verrucous (five cases) and acanthotic (eight cases) subtypes. All samples were stained using antibodies against desmoglein 1 (DSG1), desmocollin 3 (DSC3), junction plakoglobin (JUP) and serine peptidase inhibitor Kazal type 5 (SPINK5) domain. All variants of OIN3 showed significantly high rates of positivity for DSG1 in the basal layer (basaloid 57%; differentiated 85%), DSC3 in the surface layer (basaloid 93%; differentiated 77%) and JUP in the basal and parabasal layers (basaloid 93%; differentiated 62%). Interestingly, even the basaloid type showed areas of alternating DSG1 positivity and negativity, reflecting keratinocyte maturation. Therefore, most cases of OIN appear to have the characteristics of well differentiated squamous epithelium. (J Oral Sci 56, 209-214, 2014)
- 日本大学歯学部の論文
著者
-
Hasegawa Hiromasa
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
-
Ara Toshiaki
Department Of Pharmacology Graduate School Of Oral Medicine Matsumoto Dental University
-
Ochiai Takanaga
Department Of Oral Pathology Matsumoto Dental University
-
Yamada Haruki
Department of Basic Research, Oriental Medicine Research Center, Kitasato University
-
Aizawa Sohichi
Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine
関連論文
- Preventive Effects of a Kampo Medicine, Orento on Inflammatory Responses in Lipopolysaccharide Treated Human Gingival Fibroblasts
- Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts(Pharmacology)
- Silent Myocardial Ischemia in Adult Bland-White-Garland Syndrome
- Acute onset of nephrotic syndrome during interferon-α retreatment for chronic active hepatitis C
- Drug-induced MPO-ANCA-positive necrotizing crescentic glomerulonephritis preceded by granulomatous hepatitis
- Notch signaling in mandibular condylar cartilage development(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- A Case of Extracranial Atypical Meningioma Involving Maxillofacial Region
- Immunohistochemical Determination of Osteopontin Expression in Neoplastic Cells
- A Case Report of Metastatic Carcinoma of the Gingiva
- 7. Immunohistochemical study of transchondroid bone formation in duced by BMP(8th Annual Meeting of the Society of Hard Tissue Biology July 24, 1999 in Asahikawa)
- 9. Immunohistochemical localization of bone matrix proteins in heterotopic osteogenesis by BMP.
- Transchondroid Bone Formation Displayed in BMP-Induced Heterotopic Osteogenesis
- Development of Novel Therapy for Oral Diseases Using Kampo Medicines
- Lipopolysaccharide-Treated Human Gingival Fibroblasts Continuously Produce PGE_2
- Effect of Byakko-ka-ninjin-to and Gorei-san in STZ-induced diabetic saliva flow disorders mouse(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- The effect of Sho-saiko-to (TJ-9) on human gingival fibroblasts(Oral Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- A Possible Mechanism Underlying an Antidepressive-Like Effect of Kososan, a Kampo Medicine, via the Hypothalamic Orexinergic System in the Stress-Induced Depression-Like Model Mice
- Rosmarinic Acid from Perillae Herba Produces an Antidepressant-Like Effect in Mice through Cell Proliferation in the Hippocampus(Pharmacology)
- The effect of local bFGF administration for growth of mouse mandiblar head(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- LPS-stimulated Apert Syndrome Gingival Keratinocytes Show Markedly Suppressed Inflammatory Cytokine Production
- 16. Gene expression of TGF-E〓1 in the early stage of BMP-induced heterotopic osteogenesis.
- A case of anaplastic large cell (Ki-1) lymphoma of B-cell phenotype, occurring in Waldenstrom's macroglobulinemia
- Diffuse Large B-cell Lymphoma with Multinodular Proliferation Appearing in the Parotid Lymph Node
- Immunohistopathologic Study of Combined Hepatocellular-Cholangiocarcinoma
- Elevated Cystatin C Levels Predict the Incidence of Vasospastic Angina
- Measurement of Enamel Width Diameter as Basis of Stripping in Orthodontic Treatment
- Involvement of Neuropeptide Y Signaling in the Antidepressant-Like Effect and Hippocampal Cell Proliferation Induced by Kososan, a Kampo Medicine, in the Stress-Induced Depression-Like Model Mice
- Preventive Effects of a Kampo Medicine, Hangeshashinto on Inflammatory Responses in Lipopolysaccharide-Treated Human Gingival Fibroblasts
- Hepatocellular Carcinoma and Crohn's Disease: A Case Report and Review
- Effects of branched-chain amino acid granules on serum albumin level and prognosis are dependent on treatment adherence in patients with liver cirrhosis
- Heterogeneous and abnormal localization of desmosomal proteins in oral intraepithelial neoplasms