Elevated Cystatin C Levels Predict the Incidence of Vasospastic Angina
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概要
- 論文の詳細を見る
Background: Cystatin C, a marker for early stage chronic kidney disease, has been shown to be involved in cardiovascular disease. The relationship between serum cystatin C levels and coronary vasospastic angina (VSA), however, remains to be elucidated. The aim of the present study was to investigate whether elevated cystatin C levels predict the incidence of VSA. Methods and Results: One hundred and ten patients were referred to hospital due to suspected VSA. VSA was evoked in 59 patients by a vasospasm provocation test with administration of acetylcholine into the coronary arteries. The patients with VSA had lower levels of high-density lipoprotein cholesterol and a higher history of cigarette smoking, higher levels of triglyceride, high-sensitivity C-reactive protein, and higher cystatin C levels compared with those without VSA. There were no differences in serum creatinine or estimated glomerular filtration rate between patients with and without VSA. Multivariate logistic regression indicated that history of smoking (odds ratio, 2.956 P<0.05) and cystatin C levels (odds ratio, 2.285; P<0.01) were independently associated with the incidence of VSA. Conclusions: Elevated cystatin C levels were associated with higher incidence of VSA, suggesting that mild renal dysfunction may be implicated in the pathogenesis of coronary artery spasm. (Circ J 2011; 75: 2439-2444)
- 社団法人 日本循環器学会の論文
- 2011-09-25
著者
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Fukui Akio
Yamagata City Hospital Saiseikan
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Arimoto Takanori
First Department of Internal Medicine Yamagata University School of Medicine
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Watanabe Tetsu
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
-
Arimoto T
Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine
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Arimoto Takanori
Departments Of Cardiology Ishinomaki Red Cross Hospital
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Miyashita Takehiko
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Miyashita Takehiko
山形大学 医学部循環・呼吸・腎臓内科学
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Shishido Tetsuro
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Shishido Tetsuro
山形大学 医学部循環・呼吸・腎臓内科学
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Shishido Tetsuro
山形大学 循環・呼吸・腎臓内科学
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Shishido Tetsuro
First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici
-
Miyamoto Takuya
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Miyamoto Takuya
山形大学 医学部循環・呼吸・腎臓内科学
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Nitobe Joji
山形大学 医学部循環・呼吸・腎臓内科学
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Nitobe Joji
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Nitobe Joji
First Department Of Internal Medicine Yamagata University School Of Medicine
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Tamura Harutoshi
山形大学 医学部循環・呼吸・腎臓内科学
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Tamabuchi Toshiaki
Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine
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Arimoto Takanori
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Fukui Akio
Department Of Internal Medicine Yamagata Prefectural Central Hospital
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Takahashi Hiroki
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Hasegawa Hiromasa
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Fukui Akio
1st Department Of Internal Medicine Yamagata University School Of Medicine
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Inoue Minoru
Department Of Cardiology Okitama Public General Hospital
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Ishino Mitsunori
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Tominaga Makoto
Department Of Laboratory Yamagata University School Of Medicine
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Netsu Shunsuke
Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine
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Funayama Akira
Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine
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Tominaga Makoto
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Ishino Mitsunori
Department Of Cardiology Okitama Public General Hospital
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OTAKI Yoichiro
Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine
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HONDA Shintaro
Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine
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Arimoto Takanori
Division Of Cardiology Ishinomaki Red Cross Hospital
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Otaki Yoichiro
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University Of School Of Medicine
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Watanabe Tetsu
Department Of Basic Clinical Science And Public Health Tokai University School Of Medicine
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Honda Shintaro
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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