Transchondroid Bone Formation Displayed in BMP-Induced Heterotopic Osteogenesis

概要

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It has been stated that BMP induces undifferentiated mesenchymal cells to become chondrocytes in the first stage of the BMP-induced heterotopic osteogenesis. The cartilage is replaced by bone in a manner similar to that in normal endochondral (indirect) ossification. It is suggested that the BMP induced-bone occurs through an endochondral-like ossification; however the cell differentiation patterns differ from those of the normal fetal endochondral ossification process. On the other hand, intramembranous (direct) ossification is observed in some cases. Therefore, we examined histopathologically the nature of the BMP induced heterotopic osteogenesis, that is, examining histological features that are more like bone than cartilage but whose cells were not distinguishable from chondrocytes. Round chondrocytes-like cells and smaller osteocyie-like cells coexisted in the chondroid bone matrix. Furthermore, there were some chondroid patterns that still remained in the maturing bone matrix showing mosaic patterns. These findings seems to be a third ossification pattern, "transchondroid bone formation", which was described by Yasui et al. (1997) in an experimentally distraction osteogenesis model in the rat. "Chondroid bone", a tissue intermediate between bone and cartilage, was formed mainly in BMP-induced heterotopic osteogenesis.
硬組織再生生物学会の論文