Overexpression of DRG2 Increases G2/M Phase Cells and Decreases Sensitivity to Nocodazole-Induced Apoptosis
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概要
- 論文の詳細を見る
DRG2, a member of the DRG subfamily in the GTP-binding protein superfamily, was identified as a repressed gene product in fibroblasts transformed by SV40. The significance of this down-regulation and the cellular role of DRG2 has not been understood in the past. To investigate the function of DRG 2 we made a Jurkat cell line, Jurkat-LNCX2-DRG2, stably transfected with pLNCX2-DRG2 to overexpress human DRG2. Cell cycle distribution analysis revealed an increased accumulation of G2/M phase cells in Jurkat-LNCX2-DRG2 cells, indicating a retardation of cell-cycle progression. In addition, an overexpression of DRG2 reduced the sensitivity of Jurkat cells to the mitotic poison nocodazole. Our data suggest that overexpression of DRG2 in Jurkat cells affects genes regulating cell-cycle arrest and apoptosis, and that these molecular changes may be important in the growth or differentiation of cells.
- 社団法人 日本生化学会の論文
著者
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KO Myoung
Department of Biological Sciences, University of Ulsan
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Kim Sin-il
Immunomodulation Research Center University Of Ulsan
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Heo Jin
Immunomodulation Research Center University Of Ulsan
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Ko Myoung
Department Of Biological Sciences University Of Ulsan
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Song Hebok
Immunomodulation Research Center University Of Ulsan
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Lee Hae
Immunomodulation Research Center University Of Ulsan
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Kwack Kyubum
Central Genome Center National Institute Of Health
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Han In
Department Of Biological Sciences University Of Ulsan
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Park Jeong
Department Of Basic Nursing Science And Institute For Nursing Science Keimyung University College Of
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Lee Han
Department Of Biological Sciences University Of Ulsan
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Kim Hyo
Department Of Agro-environmental Sciences Faculty Of Agriculture Kyushu University
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