Sauchinone, a Lignan from Saururus chinensis, Protects Human Skin Keratinocytes against Ultraviolet B-Induced Photoaging by Regulating the Oxidative Defense System
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概要
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Ultraviolet (UV) radiation from sunlight induces matrix metalloproteinase (MMP) expression, which are responsible for collagenous extracellular matrix proteins breakdown in skin, causing photoaging. Sauchinone is reported to have various bioactivity such as antioxidative, hepatoprotective, and anti-inflammatory effects. In the present study, we investigated the protective effect of sauchinone against UVB (50 mJ/cm2)-induced photoaging in HaCaT human epidermal keratinocytes. Sauchinone, at 5–40 µ<span style="font-variant: small-caps;">M</span>, significantly protected keratinocytes against UVB-induced damage as assessed by cell viability and toxicity assay. Additionally, sauchinone, at 20–40 µ<span style="font-variant: small-caps;">M</span>, prevented the upregulation of MMP-1 proteins and reduction of type 1 collagen induced by UVB. Other assays revealed that, in keratinocytes, sauchinone decreased reactive oxygen species (ROS) production and increased glutathione levels and heme oxygenase-1. Sauchinone also inhibited UVB-induced phosphorylation of mitogen-activated protein kinase (MAPK) signaling pathways. These results demonstrated that sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes.
著者
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Kim Hyo
Department Of Agro-environmental Sciences Faculty Of Agriculture Kyushu University
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Oh Myung
Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University
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Park Gunhyuk
Department of Life and Nanopharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University
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Sim Yeomoon
Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University
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Sung Sang
Institute for Life Science, Elcomscience Co., Ltd., and College of Pharmacy, Seoul National University
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Oh Myung
Department of Life and Nanopharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University
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