Identification of the Transactivating Region of the Homeodomain Protein, Hex

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概要

• 論文の詳細を見る

• The homeodomain-containing protein Hex acts as an activator as well as a repressor of transcription in animals. While its repression domain has been mapped to the amino-terminal region, the activation domain has never been identified. Here, we show that the homeodomain and the acidic carboxyl-terminal region are necessary for full activation of the sodium-dependent bile acid cotransporter gene promoter in a cell type-independent manner, suggesting that the carboxyl-terminal region comprising residues 197 to 271 functions as the activation domain. In addition, we observed that a Hex mutant without this activation domain acts as a dominant-negative mutant as to the transactivating function of Hex.

• 社団法人 日本生化学会の論文

著者

• Miyazaki Jun-ichi

  Division Of Stem Cell Regulation Research (g6) Osaka University Graduate School Of Medicine

• Keng Vincent

  Department Of Applied Molecular Biosciences Nagoya University Graduate School Of Bioagricultural Sci

• Yamazaki Yuka

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Noguchi Tamio

  Department Of Applied Molecular Biosciences Nagoya University Graduate School Of Bioagricultural Sci

• Yamamoto Taichi

  Department Of Applied Biological Science Tokyo University Of Science

• SATO Ayuko

  Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya Uni

• Shimoda Masafumi

  Division Of Stem Cell Regulation Research Osaka University Medical School

• Kasamatsu Shinya

  Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive

• Yoshida Hiroshi

  Departmen Of Radiology School Of Medicine Asahikawa Medical University

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