Gender Difference in ICER Iγ Transgenic Diabetic Mouse
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概要
- 論文の詳細を見る
Few studies have been done to examine gender differences in diabetic mouse models. Here we examined a gender difference in Inducible cAMP Early Repressor (ICER) transgenic (Tg) mice, a diabetic mouse model. Longitudinal changes in diabetes and nephropathy were investigated in male and female Tg mice. Both male and female Tg mice developed severe diabetes early in life due to severely impaired insulin synthesis and decreased β-cell numbers, but only female Tg mice became less hyperglycemic later in life, and most female Tg mice did not develop diabetic nephropathy. Even some female Tg mice that remained hyperglycemic showed less renal expansion than age-matched male Tg mice. Thus the gender difference in the severity of diabetes and diabetic nephropathy was evident with age in this model. This study indicates that sex hormones may play a role in glucose metabolism in diabetic conditions.
- 社団法人 日本農芸化学会の論文
- 2007-08-23
著者
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Arai Hidenori
Department of Geriatric Medicine, Kyoto University Graduate School of Medicine
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Arai Hidenori
Department Of Geriatric Medicine Kyoto University Graduate School Of Medicine
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Fukatsu Atsushi
Department Of Nephrology And Cardiovascular Medicine Kyoto University
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Fukatsu Atsushi
Department Of Metallurgical Engineering Tokyo Institute Of Technology
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MIYAZAKI JUN-ICHI
Division of Stem Cell Regulation Research, G6, Osaka University Medical School
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NAGAI Kojiro
Department of Immunology, Kurume University School of Medicine
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Miyazaki Jun-ichi
Division Of Stem Cell Regulation Research (g6) Osaka University Graduate School Of Medicine
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Nagai Kojiro
Department Of Immunology Kurume University School Of Medicine
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Nagai Kojiro
Department Of Nephrology Kyoto University Graduate School Of Medicine
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Seino Yutaka
Ssp Stem Cell Unit Kyushu University Graduate School Of Medicine
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Yamada Yuichiro
Ssp Stem Cell Unit Kyushu Univ. Graduate School Of Medicine
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Yamada Yuichiro
Ssp Stem Cell Unit Kyushu University Graduate School Of Medicine
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INADA Akari
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine
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Inada Akari
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine
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