CD56 Expression in Normal Immature Granulocytes after Allogeneic Hematopoietic Stem Cell Transplantation

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概要

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• Bone marrow mononuclear cells from 93 patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation (AHSCT) were analyzed using flow cytometry (FCM). The disease was acute myeloblastic leukemia (50 patients), acute lymphoblastic leukemia, and others. Conditioning was myeloablative (80 patients) or reduced intensity. The stem cell source was bone marrow (75 patients), peripheral blood stem cells, or cord blood. After AHSCT, granulocyte colony-stimulating factor was given to all patients. All patients showed engraftment of the donor cells. FCM was conducted on a median of 22 days after AHSCT. The gate was set around a granulocytic region consisting of immature granulocytes. The positivity rates of CD13, CD14, CD15, CD33, CD34, CD56, and HLA-DR in the cells were 59.9 ± 27.4%, 5.8 ± 8.8%, 98.3 ± 1.9%, 92.3 ± 12.4%, 2.6 ± 5.8%, 24.3 ± 16.7%, and 9.1 ± 6.6%, respectively. The greatest value of CD56 positivity was 73.1%. On the basis of CD56 expression, cases of more than 24% CD56 positivity were assigned to the CD56-high group (39 patients), while the rest were assigned to the CD56-low/negative group. There were no significant differences between the two groups in terms of disease status, sex, donor, hematopoietic stem cells, days of FCM analysis, or peripheral blood cell counts around the days of performing FCM. These results indicate that CD56 can be expressed in normal immature granulocytes at a variety of expression levels in regenerative bone marrow. Attention should be paid when evaluating aberrant antigen expression of CD56 in granulocytes. [<I>J Clin Exp Hematop 53(</I><I>3</I>) <I>: 247-250, 2013</I>]

• 日本リンパ網内系学会の論文

著者

• Nagai Tadashi

  Division Of Hematology Department Of Medicine Jichi Medical University

• Okazuka Kiyoshi

  Division Of Hematology Niigata University Graduate School Of Medical And Dental Sciences

• Meguro Akiko

  Division Of Hematology Department Of Medicine Jichi Medical University

• Tatara Raine

  Division Of Hematology Department Of Medicine Jichi Medical University

• Oh Iekuni

  Division Of Hematology Department Of Medicine Jichi Medical University

• Hatano Kaoru

  Division Of Hematology Jichi Medical University

• Uehara Eisuke

  Division Of Hematology Department Of Internal Medicine Jichi Medical University

• Fujiwara Shin-ichiro

  Division Of Hematology Department Of Medicine Jichi Medical University

• Suzuki Takahiro

  Division Of Hematology Department Of Medicine Jichi Medical University

• Ohmine Ken

  Division Of Hematology Department Of Medicine Jichi Medical University

• MORI Masaki

  Division of Cell Therapy, Jichi Medical University Hospital

• Muroi Kazuo

  Division of Cell Therapy, Jichi Medical University Hospital

• Ozawa Keiya

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Mori Masaki

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Sugimoto Miyuki

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Yamamoto Chihiro

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Nagai Tadashi

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Oh Iekuni

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Fujiwara Shin-ichiro

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Ohmine Ken

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Tatara Raine

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Okazuka Kiyoshi

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Uehara Eisuke

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Hatano Kaoru

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

• Suzuki Takahiro

  Division of Cell Therapy, Jichi Medical University Hospital, Shimotsuke

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