人体頭部模型および数学モデルを用いた脳内温度分布の測定と比較

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Accurate temperature control of brain tissue during hypothermia treatment is necessary in order to prevent secondary brain damage and to avoid various side effects. Thus, visualization of intracerebral temperature distribution in hypothermia treatment was basically studied. For this purpose a technology of virtual reality was applied to synthesize a mathematical model that reflects the metabolic heat production and Fourier's heat conduction in a brain with necessary parameters from the various clinical models. In the present study, the experimental system was developed to examine the mathematical simulation concerning with blood flow of a human head by the introduction of brain solid model constructed using silicon rubber of a brain shape based on MRI data, taking into account metabolic heat given by three sheets of film heaters including six sensors for measurement of regional brain temperature. The mathematical simulation describes an internal temperature distribution of brain with similar structure of brain solid model. Results of mathematical simulation and experiment using brain solid model were well consistent in the steady state including control of regional temperature. It enables us to perform experiment of heat conduction in a similar condition of human case, in which inner temperature is clinically difficult to observe. Thus, this mathematical simulation was confirmed useful together with experiment using solid model for the study of future brain hypothermia.

人体頭部模型および数学モデルを用いた脳内温度分布の測定と比較

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