3D-visualized Model of Temperature Distribution in the Brain for the Investigation of Brain Cooling Effect

概要

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Brain hypothermia requires controlling its temperature within an appropriate range, considering the change of body temperature in a long period. Various mathematical models have been used for the study of control and cooling capability of brain temperature in hypothermia. In the previous models, a hemisphere in a lumped parameter of a uniform temperature has been assumed as a simplified brain without considering the temperature distribution. In the present study, however, a new model is proposed to visualize the temperature distribution in the brain. The model has an approximate shape of each organ in a head based on MRI data, and may well reflect the properties such as heat transfer coefficients, metabolic heat production and heat capacity of human organs. The model has a pseudo-blood-flow model in which any temperature can be set as initial value at the starting place of blood flow. Some simulations using this model are performed with its controlled temperature by the introduction of Ringer's solution into any of the four arteries to the brain. The results of simulation suggests that the various cooling effects are made clear in every region of brain, and that the temperature distribution can be known for the application of controlling brain temperature in a concerning part.