Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside
スポンサーリンク
概要
- 論文の詳細を見る
We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.
著者
-
Shigemori Hideyuki
Graduate School Of Life And Environmental Sciences University Of Tsukuba
-
Han Junkyu
Graduate School Of Life And Enviromentak Science University Of Tsukuba
-
Isoda Hiroko
Graduate School Of Life And Enviromentak Science University Of Tsukuba
-
Miyamae Yusaku
Graduate School Of Life And Environmental Sciences University Of Tsukuba
-
Irie Kazuhiro
Graduate School Of Agriculture Kyoto University
-
Murakami Kazuma
Graduate School Of Agriculture Kyoto University
-
Kurisu Manami
Graduate School of Life and Environmental Sciences, University of Tsukuba
関連論文
- Effect of Mediterranean Medicinal Plant Extracts on Melanogenesis Regulation
- Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells(MISCELLANEOUS)
- Estimation for Different Genotypes of Plants based on DNA Analysis using Near-infrared (NIR) and Fourier-transform Infrared (FT-IR) Spectroscopy
- MECHANISM OF GROWTH SUPPRESSION AT THE ILLUMINATED SIDE CAUSED BY BENZOXAZINOIDS ACCUMULATION DURING PHOTOTROPISM IN MAIZE COLEOPTILES
- Effects of seed exudates of several plant species during germination stage
- 'Malignant' Conformation of Alzheimer's β Peptides (Aβ42) through Radical Formation
- P-64 ELUICIDATION OF THE 'MALIGNATNT' CONFORMATION OF β-AMYLOID WITH ITALIAN MUTATION (E22K-Aβ42) USING SOLID-STATE NMR
- P-9 FORMATION AND STABILIZATION MECHANISM OF THE β-AMYLOID RADICAL
- Structure of β-Amyloid Fibrils and Its Relevance to Their Neurotoxicity : Implications for the Pathogenesis of Alzheimer's Disease
- Multidrug Resistance Reversal Activity of Taxoids from Taxus cuspidata in KB-C2 and 2780AD Cells
- Anti-allergic Effect of Acteoside Derived from Arid Land Plant Cistanche tubulosa
- Brasilicardin A, a New Terpenoid Antibiotic from Pathogenic Nocardia brasilienesis: Fermentation, Isolation, and Biological Activity
- Brasilicardin A ; a New Terpenoid Antibiotic Produced by Nocardia brasiliensis
- P-38 ANALYSIS OF CH/π INTERACTION BETWEEN TUMOR PROMOTERS AND PROTEIN KINASE C C1 DOMAINS
- Selective Binding of Tumor Promoters to the Novel PKC C1B Domains
- Effect of Capsaicin on the Tight Junctional Permeability of the Human Intestinal Cells
- Adjustment of the Water Environment by Wastewater Treatment
- New Aggregation Model of Amyloid β by the Systematic Proline Replacement
- Structure–Activity Relationship of Caffeoylquinic Acids on the Accelerating Activity on ATP Production
- Growth of Semipolar (1122) GaN Layer by Controlling Anisotropic Growth Rates in r-Plane Patterned Sapphire Substrate
- Pycnalin, a New α-Glucosidase Inhibitor from Acer pycnanthum
- P-562 New Bioactive Substances Involved in Growth Regulation from Arabidopsis thaliana
- P-394 PLANT-GROWTH INHIBITORY POLYACETYLENES FROM GALLS AND NORMAL TISSUES OF HEDERA RHOMBEA
- Naucleamides A-E, New Monoterpene Indole Alkaloids from Nauclea latifolia
- Stomatal Density is Controlled by a Mesophyll-Derived Signaling Molecule
- Induction of Growth Inhibition and Differentiation of Human Leukemia HL-60 Cells by a Tunisian Gerboui Olive Leaf Extract
- Inhibitory Effect of Fulvic Acid Extracted from Canadian Sphagnum Peat on Chemical Mediator Release by RBL-2H3 and KU812 Cells
- Effect of Tunisian Capparis spinosa L. extract on melanogenesis in B16 murine melanoma cells
- Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer's Disease Mouse Model
- The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide : The emerging role in the pathogenesis of Alzheimer's disease
- Properties of Fulvic Acid Extracted from Excess Sludge and Its Inhibiting Effect on β-Hexosaminidase Release
- First Total Synthesis of 4-Methylthio-3-butenyl Glucosinolate
- Effects of silkworm powder on glucose absorption by human intestinal epithelial cell line Caco-2
- Palmaenones A and B, Two New Antimicrobial Chlorinated Cyclopentenones from Discomycete Lachnum palmae
- Stimulation of the Amyloidogenic Pathway by Cytoplasmic Superoxide Radicals in an Alzheimer's Disease Mouse Model
- Identification and Biological Activities of Bryostatins from Japanese Bryozoan
- Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor
- Soil Amendment by Sediment from Water Storage Reservoir as a Restoration Technique in Secondary Treated Wastewater Irrigated Area at El Hajeb Region (Sfax-Tunisia)
- Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside
- Induction of Hepatocyte Growth Factor Production in Human Dermal Fibroblasts by Caffeic Acid Derivatives