Pycnalin, a New α-Glucosidase Inhibitor from Acer pycnanthum
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概要
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A new compound, pycnalin (1), together with four known compounds, ginnalins A (2), B (3), C (4), and 3,6-di-O-galloyl-1,5-anhydro-D-glucitol (3,6-di-GAG) (5), were isolated from Acer pycnanthum. The structure of 1 was determined on the basis of 2D-NMR spectral data and synthesis of 1. Pycnalin (1) is the first 1,5-anhydro-D-mannitol linked to a gallic acid, while compounds 2—5 were 1,5-anhydro-D-glucitol linked to gallic acids. All compounds were tested in vitro for α-glucosidase inhibitory and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. Pycnalin (1) exhibited moderate α-glucosidase inhibitory activity as well as free radical scavenging activity. Ginnalin A (2) and 3,6-di-GAG (5), which have two galloyl groups, exhibited potent α-glucosidase inhibition, compared to those of other compounds 1, 3, and 4 containing a galloyl group. These results suggest that α-glucosidase inhibition is influenced by the number of galloyl groups.
著者
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MIYAMAE Yusaku
Graduate School of Life and Environmental Sciences, University of Tsukuba
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SHIGEMORI Hideyuki
Graduate School of Life and Environmental Sciences, University of Tsukuba
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Shigemori Hideyuki
Graduate School Of Life And Environmental Sciences University Of Tsukuba
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Miyamae Yusaku
Graduate School Of Life And Environmental Sciences University Of Tsukuba
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YAZAWA Kazunaga
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology
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Ogawa Ai
Graduate School of Life and Environmental Sciences, University of Tsukuba
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Honma Atsushi
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology
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Koyama Tomoyuki
Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology
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Koyama Tomoyuki
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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Honma Atsushi
Laboratory Of Nutraceuticals And Functional Foods Science Graduate School Of Marine Science And Tech
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Yazawa Kazunaga
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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