Hypouricemia in View of the Alternation of Liver Function Test in Course of Time

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We examined hypouricemia in admitted patients (31 cases) and obtained the following conclusion. 1) In all cases, hypouricemia was transient. 2) Hypouricemia associated with liver disease was found in 21cases among 31 cases (68%) and liver dysfunction was relative mild. 3) We observed the clinical course of the alternation of liver function test and uric acid concentration in course of time. Hypouricemia in one group appeared in the same time of the worse change of liver function, and hypouricemia in the other group appeared after the worse change of liver function. 4) In one case of hypouricemia, serum and urine oxypurine concentration increased as liver function became worse. It is suggested that hypouricemia may be affected by xanthine oxidase.
Japanese Society of Gout and Nucleic Acid Metabolismの論文