Acute Hemodynamic Effect of Cardiac Resynchronization Therapy Derived from Phase Analysis on Gated Myocardial Perfusion Spect
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概要
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<B>Background:</B> Quantitative Gated SPECT (QGS)-derived phase analysis on gated myocardial perfusion SPECT (GMPS) has been reported to predict long term clinical response to Cardiac resynchronization therapy (CRT). However, acute effects of CRT detected from phase analysis on GMPS are uncertain. <B>Methods:</B> Seven heart failure patients who had been previously undergone CRT with evaluation of clinical effectiveness, were studied. First, GMPS was performed on the condition of on-mode of CRT pacing. After 20-minute switching-off the pacing, GMPS was obtained again. Phase analysis data and cardiac function were calculated by QGS software. <B>Results:</B> Left ventricular end-diastolic volume and ejection fraction derived from phase analysis remained unchanged by CRT. Histogram bandwidth and phase SD became smaller (123±69° vs 83±77°, p<0.05; 34±21° vs 23±17°, p<0.01, respectively) by biventricular pacing. As a diastolic parameter, 1/3 mean filling rate got larger (0.49±0.36 vs 0.68±0.39, p<0.0001) by CRT. <B>Conclusions:</B> CRT was shown to reduce LV dyssynchrony and improves diastolic function by GMPS, as an acute effect. Phase analysis in GMPS may be a suitable method to evaluate the effect of CRT on diastolic function.
著者
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Matsuo Shinro
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Takashima Shinichiro
Department of Disease Control and Homeostasis, Kanazawa University
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Kaneko Shuichi
Department Of Cancer Gene Regulation Kanazawa University
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Takamura Masayuki
Department Of Cardiology Graduate School Of Medical Science Kanazawa University
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Furusho Hiroshi
Department Of Disease Control And Homeostasis Graduate School Of Medical Science Kanazawa University
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Usui Soichiro
Department Of Disease Control And Homeostasis Graduate School Of Medical Science Kanazawa University
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Furusho Hiroshi
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
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Usui Soichiro
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
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Furusho Hiroshi
Department Cardiology, Kanazawa University Hospital
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Takashima Shinichiro
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University
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Takamura Masayuki
Department Cardiology, Kanazawa University Hospital
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Takamura Masayuki
Department of Nuclear Medicine, Kanazawa University Hospital
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Usui Soichiro
Department Cardiology, Kanazawa University Hospital
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