The relationship between stress-induced myocardial ischemia and coronary artery atherosclerosis measured by hybrid SPECT/CT camera
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概要
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Objective: The coronary artery calcium (CAC) score and myocardial perfusion imaging can now be detected simultaneously using a hybrid SPECT/CT camera. However, there has been little evaluation on the relationship between stress-induced ischemia and coronary artery calcification in a Japanese population. The aim of this study was to investigate the relationship between these parameters and to elucidate the diagnostic value of the CAC score as an adjunct to myocardial perfusion imaging (MPI) for the assessment of coronary artery disease (CAD) in an intermediate-risk population. Methods: We retrospectively analyzed 105 patients (63% men, mean age 71 years) with CAD or suspected CAD who underwent MPI using SPECT/CT. CAC scanning was performed using a SPECT/CT camera. Results: There was a significant difference in the CAC score between patients with ischemia (n = 42) and those without ischemia (n = 63) (1353 ± 1524 vs. 332 ± 554, p < 0.01). The frequency of ischemic MPI determined by summed difference score tended to be higher in patients with high CAC (CAC = 0; 0.8 ± 1.3 vs. CAC > 1000; 3.0 ± 2.0). Higher age is related roughly with higher CAC score with no statistical significance (r 2 = 0.1) (<60 years old; 200 ± 692, vs. >80 years old; 1258 ± 1546, ns). The location of calcification was not related to the ischemic area. In a population with a predominately intermediate likelihood of CAD, a calcium score of zero has a possibility of excluding inducible ischemia on MPI. In part, ischemic MPI is associated with a high likelihood of subclinical atherosclerosis as detected by CAC. Conclusion: Hybrid SPECT/CT might be useful for diagnostic assessment and coronary artery with known or suspected CAD. © 2011 The Japanese Society of Nuclear Medicine.
- 2011-11-01
著者
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絹谷 清剛
金沢大学バイオトレーサ診療学
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NAKAJIMA Kenichi
Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences
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Kinuya Seigo
金沢大学 自然科学研究科
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Kinuya Seigo
Graduate School Of Medical Sciences Kanazawa University
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Nakajima Kenichi
Kanazawa Univ. Hospital Kanazawa Jpn
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Kinuya Seigo
金沢大学 医学系研究科バトオトレーサー診療学
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絹谷 清剛
金沢大学医学部
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Kuniya S
Kanazawa Univ. School Of Medicine Kanazawa
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Matsuo S
Department Of Nuclear Medicine Kanazawa University Hospital
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Matsuo Shinro
滋賀医科大学 内科学第一
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Matsuo Shinro
滋賀医科大学 呼吸循環器内科
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Matsuo Shinro
Kanazawa Univ. Hospital Kanazawa Jpn
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Matsuo Shinro
Department Of Nuclear Medicine Kanazawa University Hospital
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Matsuo Shinro
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Matsuo Shinro
日本大学 医学部循環器内科部門
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Shiba Kazuhiro
Radioisotope Center Kanazawa University
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Okuda Koichi
Department Of Biotracer Medicine Kanazawa University
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Kinuya Seigo
Department Of Biotracer Medicine Kanazawa University Graduate School Of Medical Sciences
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Nakajima Kenichi
Kanazawa Univ. Kanazawa Jpn
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Kinuya Keiko
Department Of Nuclear Medicine Kanazawa University Hospital
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Kinuya S
Department Of Nuclear Medicine Kanazawa University School Of Medicine
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絹谷 清剛
金沢大学医学部核医学科
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Nakajima Kenichi
Department Of Nuclear Medicine Kanazawa University
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Matsuo Shinro
Division Of Cardiology Department Of Medicine Shiga University Of Medical Science
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Kanayama Sugako
Department Of Nuclear Medicine Kanazawa University Hospital
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Nakajima Kenichi
Department Of Nuclear Medicine
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Nakajima Kenichi
金沢大学附属病院 核医学
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