Scintigraphic Evaluation of Cardiac Metabolism and Sympathetic Nerve Function in Alcoholic Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
A 70-year-old man with alcoholic cardiomyopathy underwent 99mtechnetium-sestamibi (MIBI), iodine-123-labeled metaiodobenzylguanidine (MIBG) scintigraphy and Iodine-123-labeled beta-methyl-iodophenyl pentadecanoic acid (BMIPP) scintigraphy. 99mTechnetium-MIBI identified myocardial damage in the inferior wall of left ventricle. 123I BMIPP showed low uptake in the inferior wall of the myocardium, concordant to perfusion. 123I BMIPP and 123I MIBG showed reduced uptake in the inferior segment of the myocardium, indicating impairment of fatty acid metabolism and sympathetic abnormalities. Damaged myocardium was demonstrated in alcoholic cardiomyopathy. Beta blocker (carvedilol) and angiotensin-receptor blocker (valsartan) were started at low doses, then increased gradually, leading to the improvement of cardiac performance. Cardiac sympathetic nerve function, impaired due to alcoholic cardiomyopathy, was improved with beta-blocker therapy. Cardiac scintigraphy may be useful to assess the extent of myocardial improvement and the response to therapy.
著者
-
Matsuo Shinro
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
-
Nakae Ichiro
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
-
Horie Minoru
Department Of Cardiac Physiology National Cardiovascular Center Research Institute
-
Matsumoto Tetsuya
Department Of Cardiovascular And Respiratory Medicine
-
MASUDA Daisuke
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
関連論文
- Attenuation correction of myocardial SPECT by scatter-photopeak window method in normal subjects
- Comparison of the long-term effects of candesartan and olmesartan on plasma angiotensin II and left ventricular mass index in patients with hypertension
- FRS-031 Additional Gene Modifiers Reduce Effectiveness of β-blockers in the Long QT Type 1 Syndrome(Arrhythmia-Basic : Molecular and Genetic : Basis (A) : FRS4)(Featured Research Session (English))
- ECG Findings in Andersen's Syndrome : Action Potential Simulation Study
- NRSF Is Involved in Molecular Pathways for Sudden Death Associated with Heart Failure
- Hydroxyzine, a First Generation H_1-Receptor Antagonist, Inhibits Human Ether-a-go-go-Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation
- PJ-630 Clinical Usefulness of Fusion Imaging System by Using 64-Section MDCT and Cardiac SPECT(PJ106,Nuclear Cardiology (Others) (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-048 Temporal Assessment of Tenascin-C Expression after Myocardial Ischemia and Reperfusion using I-125-anti Tenascin-C Antibody(FRS10,Updates in Nuclear Cardiology (I),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japan
- Prognostic Value of Non-Obstructive CT Low-Dense Coronary Artery Plaques Detected by Multislice Computed Tomography
- PJ-571 Multiple Mechanisms underlie Long QT Syndrome by the Change of Amino Acid R259 in the Intracellular S4-S5 Linker of KCNQ1(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
- PE-106 SCN5A and Lamin A/C Gene Mutations are Highly Prevalent in Patients with Familial Bradyarrhythmic Disorders(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- Association of Atrial Arrhythmia and Sinus Node Dysfunction in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
- Whole-Body Periodic Acceleration Enhances Brachial Endothelial Function
- PJ-457 Chronic Effects of Angiotensin II Receptor Blockade on Coronary Fibrinolytic Function in Patients with Coronary Artery Disease(Coronary circulation, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-453 Effects of Chronic Smoking on Coronary Fibrinolytic Function in Women with Normal Coronary Arteries(Coronary circulation, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample : The Shigaraki Study
- The Association between Morning Hypertension and Metabolic Syndrome in Hypertensive Patients
- Impact of Paraoxonase Polymorphism (Q192R) on Endothelial Function in Intact Coronary Circulation
- PJ-772 The Present Condition of the Morning Hypertension Patients after JSH2004(Hypertension, clinical-12 (H) PJ134,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-689 Relationship between a Metabolic Syndrome and the Polymorphism of the Beta3 Adrenergic Receptor Gene in a General Sample (S-town study)(Diabetes/Obesity/Metabolic syndrome-13 (H) PJ116,Poster Session (Japanese),The 70th Anniversary Annual Scientifi
- PJ-388 The Impact of Whole-body, Periodic Acceleration on Vascular Endothelial Function and Nitric Oxide Release(Exercise test/Cardiac rehabilitation-3 (IHD) PJ66,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
- PJ-010 Aortic Stiffening Precedes Coronary Endothelial Dysfunction in Type II Diabetes Mellitus(Coronary circulation, basic/clinical-4 (IHD) PJ2,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-149 Mutation Site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in Japanese Families with Congenital LQT1 Syndrome(Sudden Cardiac Death (A) : FRS18)(Featured Research Session (English))
- 5 Genotype- and Mutation site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in the Long QT Syndrome(APSC/JCS Joint Symposium (APSC) (H) : Emerging Issue in Cardiology for Asian)(Special Program)
- Novel Mutation of Plakophilin-2 Associated With Arrhythmogenic Right Ventricular Cardiomyopathy
- A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation
- Combined Analysis of Polymorphisms in Angiotensinogen and Adducin Genes and Their Effects on Hypertension in a Japanese Sample : The Shigaraki Study
- Change of Medication to Candesartan is Effective for Patients with Early Morning Surge in Blood Pressure (from the ATOM Study) (Hypertension, Clinical 10 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Molecular Basis for Low Penetrance in the Long QT Syndrome(Meet the Expert 7 (ME7) (A) : Issues on Sudden Cardiac Death)(Special Program)
- Molecular and Genetic Basis for the Treatment of Long QT-Related Lethal Ventricular Arrhythmias
- Verapamil binding sites of K_ channel may reside on the cytosolic end of the TM2 of the pore-forming subunit, Kir6.2
- Why does intracoronary ACh injection induce torsade de pointes in long QT syndrome? : Role of Nitric Oxide
- Therapeutic concentrations of bepridil voltage-dependently block of IK_s reconstituted by KCNQ1/KCNE1
- LQT1, but not LQT2, patients show an exercise-induced increase in transmural dispersion of repolarization (TDR)
- Electrical Remodeling of the Ventricular Myocardium in Myocarditis : Studies of Rat Experimental Autoimmune Myocarditis
- The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine Working Group Database
- OJ-012 Mutation Analysis for the Human Cardiac Ryanodine Receptor Gene (RyR2) in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Soci
- PE-104 Severer Phenotypes of Long QT Syndrome are Associated with Compound Mutations : A Multicenter Study(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- FRS-052 Identification and Functional Characterization of a Novel Intronic Splicing Mutation in KCNQ1 Associated with Long QT Syndrome(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientifi
- 2 Latent Genetic Backgrounds and Molecular Pathogenesis of Drug-induced Long QT Syndrome(Proarrhythmic Risk of Drugs and Their Evaluation,Symposium 7 (SY-07) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 1 A Novel Genetic Marker for Potential Risk of QT Prolongation and Cardiac Sudden Death : KCNE1-D85N Polymorphism(Biomarkers, Genetic Polymorphism, and Risk Estimation,Symposium 1 (SY-01) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation
- Role of Impaired Sympathetic Nerve Function in Enhancing Coronary Vasoconstriction in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Endothelial Dysfunction May Play a Role in Left Ventricular Remodeling after Primary Coronary Angioplasty for Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Pathophysiology) 4 (IHD), The 69th Annual Scientific Meeting of the Japanese C
- OE-094 Noninvasive Evaluation of Coronary Artery Plaque with ECG-Gated Multislice Computed Tomography(X-ray/CT/MRI/DSA 1 (I) : OE11)(Oral Presentation (English))
- Prognostic Value of Myocardial Perfusion Single-Photon Emission Computed Tomography for the Prediction of Future Cardiac Events in a Japanese Population : A Middle-Term Follow-up Study
- Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging
- Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population : A Study Based on the J-ACCESS Study
- Body Mass Index Is an Independent Determinant of Coronary and Peripheral Endothelial Function
- The Relationship between Aortic Pulse Wave Velocity and Coronary Endothelial Function
- Endogenous Coronary Fibrinolytic Activity Is Reduced in Patients with Type II Diabetes : Effects of Coronary Tissue Plasminogen Activator Release
- OE-362 Prognostic Value of Normal Stress Myocardial Perfusion Imaging in Japanese Population : a study Based on the J-ACCESS Study(Nuclear cardiology(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-158 Novel Anatomical Observations of the Left Atrium and the Pulmonary Vein by Multi-Detector Computed Tomography in Patients with Atrial Fibrillation(CT/DSA-1 (I) OE27,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the J
- Multidetector-Row Computed Tomography Coronary Angiography : Optimization of Image Reconstruction Phase According to the Heart Rate
- Prognostic value of ECG-gated thallium-201 single-photon emission tomography in patients with coronary artery disease
- Relationship between exercise capacity and cardiac diastolic function assessed by time-volume curve from 16-frame gated myocardial perfusion SPECT
- PJ-532 Angiotensin-Converting Enzyme Inhibition Increases Constitutive Release of Tissue Plasminogen Activator in Coronary Circulation(PJ090,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Poster Session (Japanese),The 73rd Annual Sci
- PJ-445 Clinical Difference of Radial Augmentation Index and Pulse Wave Velocity as Indicators of Cardiovascular Stiffness(PJ075,Hypertension, Clinical 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure : Comparison With Enalapril
- Clinical significance of diastolic function as an indicator of myocardial ischemia assessed by 16-frame gated myocardial perfusion SPECT
- PE-274 Cardiac Diastolic Function as an Indicator of Myocardial Ischemia Estimated by 16-Frame Gated Myocardial Perfusion SPECT(Cardiac function, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation
- Assessment of cardiac function in patients with heart disease by quantitative gated myocardial perfusion SPECT
- PE-362 A Novel Clinical Indicator Using Tc-99m Sestamibi for Evaluating Cardiac Mitochondrial Function in Patients with Cardiomyopathies(Nuclear cardiology-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-096 Creatine Kinase System and Fatty Acid Metabolism in Human Failing Hearts(Metabolism/Biochemistry/Energetics-3 (M) PJ16,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-061 Cardiac Diastolic Dysfunction is Associated with Sympathetic Nerve Functional Abnormalities in Patients with Stable Heart Failure(Cardiac function, basic/clinical-3 (M) PE11,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of
- Impact of endothelial dysfunction on left ventricular remodeling after successful primary coronary angioplasty for acute myocardial infarction : Analysis by quantitative ECG-gated SPECT
- Left ventricular systolic/diastolic function evaluated by quantitative ECG-gated SPECT : comparison with echocardiography and plasma BNP analysis
- Myocardial Creatine Concentration in Various Nonischemic Heart Diseases Assessed by ^1H Magnetic Resonance Spectroscopy
- Dilated cardiomyopathy relieved as a result of β-blocker therapy : A case report-key points in assessment of prognosis based on MIBG myocardial scintigraphy and BNP levels
- The Effect of Cardiac Resynchronization Therapy (CRT) in Patients with Severe Left Ventricular Dysfunction : Evaluation by Quantitative Gated SPECT (QGS)(Nuclear Cardiology 5 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Myocardial Fatty Acid Metabolism in Patients with Cardiac Dysfunction(Metabolism/Biochemistry/Energetics 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical usefulness of novel cardiac MDCT/SPECT fusion image
- PJ-350 Increased Levels of Lipocalin-type Prostaglandin D Synthase is associated with Plaque Instability in Human Coronary Circulation(Coronary circulation, basic/clinical-5 (IHD) PJ59,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeti
- Assessment of Myocardial Creatine Concentration in Dysfunctional Human Heart by Proton Magnetic Resonance Spectroscopy
- PE-463 Prognostic Value of Post-Stress Left Ventricular Function by ECG-gated Tl Scintigraphy(Cardiac Function, Basic/Clinical 3 (M) : PE79)(Poster Session (English))
- PE-215 Assessment of Myocardial Creatine Concentration by Proton Magnetic Resonance Spectroscopy in Dysfunctional Human Heart(Metabolism/Biochemistry/Energetics 1 (IHD) : PE37)(Poster Session (English))
- PE-035 Prognostic Value of Iodine-123 Metaiodobenzylguanidine Imaging in Patients with Heart Failure(Nuclear Cardiology 4 (I) : PE6)(Poster Session (English))
- PE-155 Relationship between Exercise Capacity and Left Ventricular Diastolic Function by Time-volume Curve Analysis(PE026,Cardiac Function (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-442 Gender Differences in Coronary Microvasomotor Function in Patients with Coronary Vasospastic Angina(Coronary circulation, basic/clinical(04)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-469 Relationship between Aortic Stiffness and Muscarinic and Bradykinin Receptor-Operated Coronary Vasomotor Responses(Coronary Circulation, Basic/Clinical 4 (IHD) : PJ78)(Poster Session (Japanese))
- PJ-467 Effects of Pravastatin on Endothelium-dependent Coronary Vasomotor and Fibrinolytic Function(Coronary Circulation, Basic/Clinical 4 (IHD) : PJ78)(Poster Session (Japanese))
- OJ-322 Effects of Diabetes on Coronary and Forearm Endothelial Function and Aortic Stiffness(Cardiovascular Pharmacology, Basic/Clinical 2 (H) : OJ39)(Oral Presentation (Japanese))
- Evaluation of Myocardial Metabolism in Asynergic Segments of Ischemic Myocardium Using 31P and 1H Magnetic Resonance Spectroscopy
- Effects of Hypertension on Brachial Artery Flow-Mediated Dilation and Coronary Vasomotor Responses to Bradykinin and Acetylcholine
- Detection of Calf Muscle Alteration in Chronic Heart Failure by 31p Magnetic Resonance Spectroscopy : Impaired Adaptation to Continuous Exercise
- In Vivo Vasodilatory Action of Atrial Natriuretic Peptides in Canine Coronary Circulation
- Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes: A study based on the J-ACCESS-2 database
- Lipocalin-Type Prostaglandin D Synthase Is Associated With Coronary Vasospasm and Vasomotor Reactivity in Response to Acetylcholine
- Assessment of diastolic function using 16-frame 201Tl-gated myocardial perfusion SPECT
- Scintigraphic Evaluation of Cardiac Metabolism and Sympathetic Nerve Function in Alcoholic Cardiomyopathy
- Effect of Atorvastatin vs. Rosuvastatin on Cardiac Sympathetic Nerve Activity in Non-Diabetic Patients With Dilated Cardiomyopathy
- Estimation of Cardiac Event Risk by Gated Myocardial Perfusion Imaging and Quantitative Scoring Methods Based on a Multi-Center J-ACCESS Database
- Cardiac Event Risk in Japanese Subjects Estimated Using Gated Myocardial Perfusion Imaging, in Conjunction With Diabetes Mellitus and Chronic Kidney Disease
- Quantification of myocardial perfusion SPECT using freeware package (cardioBull)
- The relationship between stress-induced myocardial ischemia and coronary artery atherosclerosis measured by hybrid SPECT/CT camera
- Relationship between Nonspecific Electrocardiographic Abnormalities and Left Ventricular Performance in Coronary Atherosclerosis
- Acute Hemodynamic Effect of Cardiac Resynchronization Therapy Derived from Phase Analysis on Gated Myocardial Perfusion Spect
- Phase analysis using gated myocardial perfusion single-photon emission computed tomography imaging for evaluating cardiac dyssynchrony
- Evaluation of cardiac resynchronization therapy in drug-resistant dilated-phase hypertrophic cardiomyopathy by means of Tc-99m sestamibi ECG-gated SPECT
- J-Point Elevation Induced by Double Master Two-Step Test
- Noncompaction of the ventricular myocardium mimicking ischemic cardiomyopathy