Relationship between Nonspecific Electrocardiographic Abnormalities and Left Ventricular Performance in Coronary Atherosclerosis
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概要
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<B>Background:</B> Nonspecific ST-T abnormalities (NSSTTA) have been associated with increased risk of cardiovascular mortality. The aim of this study was to investigate relationship between NSSTTA and left ventricular (LV) performance in coronary atherosclerosis. <B>Methods:</B> We reviewed 12-lead ECG in patients undergoing coronary angiography and echocardiography. NSSTTA (nonspecific ST-segment depression (≤−50 µV) and/or T-wave inversion (≤−100 µV) was interpreted by computerized analysis. The role of NSSTTA in atherosclerogenesis and LV performance was determined. <B>Results:</B> Inclusion criteria were met by 323 patients. LV mass was significantly greater in patients with NSSTA than those without (261.7 grams versus 217.9 grams, P=0.001). LV diastolic performance was significantly lower in patients with NSSTTA than those without (8.9 versus 7.0 represented by E/E′, P=0.014). However, there was no significant difference in LV ejection fraction between patients with and without NSSTTA (62.0% versus 63.2%, P=0.387). In addition, no significant association between NSSTTA and the severity of coronary stenosis was found (19.1 versus 17.9 expressed by Gensini score, P=0.762). Multivariate analysis identified that an independent determinants of NSSTTA was LV mass (P=0.008). <B>Conclusions:</B> NSSTTA was identified as a novel risk factor for initiating cardiovascular continuum.
著者
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HORIE Minoru
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Nakae Ichiro
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Yoshino Tomohide
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Horie Minoru
Department Of Cardiac Physiology National Cardiovascular Center Research Institute
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Naiki Nobu
Department Of Cardiology Nagahama City Hospital
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Taniguchi Atsushi
Department Of Cardiology Nagahama City Hospital
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Matsumoto Tetsuya
Department Of Cardiovascular And Respiratory Medicine
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Miyamoto Akashi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Kawaguchi Tamiro
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Hayashi Hideki
Department Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka
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