タイトル無し

概要

論文の詳細を見る
The effect of captopril, an inhibitor of angiotensin converting enzyme, on cardiovascular hemodynamics was studied in 7 patients with chronic congestive heart failure. After single oral administration of 25 mg, systemic blood pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac output, heart rate, plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured for 4 hours.<BR>Systemic blood pressure was measured by a sphygmomanometer, pulmonary arterial and capillary wedge pressure by an electromanometer, and cardiac output by thermodilution method.<BR>Captopril produced a significant decrease in systemic blood pressure, pulmonary arterial and capillary wedge pressure. Cardiac output did not change significantly. PRA showed a significant increase throughout the observation. PAC showed a significant decrease from 2 hours after administration.<BR>These results suggest that captopril has a potency of ameliorating congestive heart failure through the reduction of left ventricular afterload and preload and the suppression of renin-angiotensin-aldosterone axis.
一般社団法人日本臨床薬理学会の論文