:In Vitro and In Vivo Studies

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The present study was undertaken to estimate in vitro and in vivo effects of dilazep on the hemoglobin-oxygen dissociation curve of venous blood from 16 healthy men. Dilazep (5×10-6 to 5×10-4M) significantly shifted the oxygen dissociation curve of the hemoglobin to the right but did not affect the 2, 3-DPG contents on incubation of blood samples for 2 to 4 hours with the drug. In vivo administration of dilazep (300mg/day for one week), however, produced a significant shift of the curve to the left. This leftward shift was accompanied with a tendency for contents of 2, 3-DPG to decrease without a significant changes in HbAIC levels. There were no changes observed in P50, 2, 3-DPG and HbAlc levels with a lower dosage of dilazep (150 mg/day for oneweek). These findings suggested that the increased oxygen binding to hemoglobin induced by dilazep in vivo resulted from a probable increase in systemic oxygen delivery due to its vasodilating effects.
一般社団法人日本臨床薬理学会の論文