Effects of 2-nicotinamidoethyl nitrate (nicorandil) on hemodynamic responses to supine bicycle ergometer exercise in patients with prior myocardial infarction.

概要

論文の詳細を見る
To investigate hemodynamic effects of a new coronary vasodilator, 2-nicotinami doethyl nitrate (nicorandil), 12 patients with prior myocardial infarction were stu died. Patients with angina pectoris were excluded.<BR>Hemodynamic measurements were made during supine bicycle ergometer exercise testings before and 60 min after single oral administration of 15 mg of nicorandil. Symptom-limited exercise testing was performed before nicorandil, and after nicoran dil the same workload was assigned to each patient. At peak exercise, there was a significant increase in cardiac index, while stroke volume index remained unchanged after nicorandil. Both at rest and at peak exercise, there was a significant decrease in systolic and diastolic blood pressure, systemic vascular resistance, and pulmonary capillary wedge pressure after nicorandil. Coronary sinus blood flow was significant ly increased and coronary vascular resistance was significantly decreased after nicor andil both at rest and peak exercise. The average value for plasma nicorandil concen tration was 215ng/ml 60min after dosing.<BR>These data would indicate that nicorandil exhibits a beneficial effect on hemodyna mic responses to exercise in patients with prior mycoardial infarction by reduction of left ventricular preload and afterload and by increment in coronary blood flow.