Hemodynamic effect of nipradilol (K-351) in essential hypertension.

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Nipradilol (K-351) is a new type of beta-blocker with vasodilating action. In this paper, the hemodynamic effect of nipradilol was studied non-invasively using 10 hypertensive patients. Nipradilol was orally given to patients with mild or moderate essential hypertension for about 3 months, and blood pressure (BP), heart rate (HR), cardiac output (CO), and systolic time intervals (STI) were measured, respectively. As results in the responder patients, both BP and HR decreased significantly, CO remained unchanged, and the total peripheral resistance (TPR) tended to decrease. In STI, the ejection time (ET) prolonged, the preejection period (PEP) shortened slightly, and ET/PEP increased.<BR>Accordingly, the hemodynamic effect of nipradilol was different from that of propranolol, probably due to the vasodilating action of nipradilol.