The effect of nitrendipine on hemodynamics during excercise in effort angina pectoris with old myocardial infarction.

概要

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Nitrendipine is a dihydropyridine calcium entry blocker. The effect of nitrendipine on hemodynamics at rest and during exercise with a supine bicycle ergometer with multistage protocol was studied in 10 cases of effort angina pectoris with old myocardial infarction.<BR>Nitrendipine was given orally at a daily dose of 10 mg for one week and various hemodynamic parameters were measured at rest and during exercise before and after the treatment with nitrendipine. At rest, the blood pressure was reduced, total peripheral resistance and pulmonary artery pressure tended to decrease, heart rate, cardiac index and stroke index were unchanged, and left ventricular ejection fraction tended to increase.<BR>At peak exercise, the blood pressure tended to decrease, heart rate, cardiac index and stroke index tended to increase, the rise in pulmonary artery pressure was suppressed, the pulmonary vascular resistance decreased, and the decrease in the left ventricular ejec tion fraction was reduced.<BR>It is concluded that nitrendipine exerts antianginal action without decreasing cardiac function.
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