Elevation of Serum Transaminase Value after Administration of Non-toxic Drugs in Some Volunteers for Phase I Trials: A Study on the Selection of Volunteers.
スポンサーリンク
概要
- 論文の詳細を見る
A total of 237 healthy male volunteers took drugs for phase I trials. Serum transaminase values (GOT and GPT) were maintained within normal ranges in most of them. However, GOT or GPT was elevated to an abnormal level in 9.3% of them after the administration.After investigating the clinical features of the "transaminase-elevated group" and the "non-elevated group", we concluded that GOT or GPT is likely to be elevated in subjects with GOT<GPT, high obesity index, high serum γ-glutamyl transpeptidase, or a combination of any of the three. These subjects should be excluded from phase I trials for an accurate evaluation of the safety of a drug.
著者
-
Yamada Nobuo
Department Of Dermatology Tokyo University Branch Hospital
-
Nishikawa Takashi
Department of Biotechnology, Graduate School of Engineering, Osaka University
-
SHIBATA Hisao
Division of Clincal Pharmacology, Kitasato University East Hospital
-
KOBAYASHI Minae
Division of Clincal Pharmacology, Kitasato University East Hospital
関連論文
- Spin Structure of S=1/2 Quantum Spin System CaV_3O_7
- Datapath-Layout-Driven Design for Low-Power FPGA Implementation (特集:電子システムの設計技術と設計自動化)
- Introduction of the Archaebacterial Geranylgeranyl Pyrophosphate Synthase Gene into Chlamydomonas reinhardtii Chloroplast
- Specific Heat of Quasi-One-Dimensional Spin 1/2 System CuNb_2O_6
- Magnetic Order in High-T_c Superconductor La_Sr_xCaCu_2O_6 : La NQR Study
- Substitution Effects on the Thermoelectric Power of La_Sr_xCu_M_yO_4 (M=Zn and Ni) and YBa_2Cu_Zn_yO_
- Transport, Magnetic and Thermal Properties of La_3Ni_2O_
- Transport Anomalies of High-T_c Oxides above Room Temperature
- Anomalous Behavior of Hall Coefficient and Thermoelectric Power of YBa_2Cu_3O_ and La_Sr_xCuO_4 above Room Temperature
- Anomalous Temperature Dependence of the Hall Coefficient in La_Sr_xCuO_4 above Room Temperature
- Thermal Properties of Two Dimensional Mott System La_Sr_xVS_
- Effects of Carrier Doping into the Misfit-Layer Compounds (La_R_yS)_VS_2 (R=Sr and Pb) : Transport and Magnetic Studies
- Spin Gap Behavior of S=1/2 Quasi-Two-Dimensional System CaV_4O_9
- Transport Anomalies of Misfit-Layer Compounds La_Sr_xVS_ with Mott Metal-Insulator Transition
- Increased tau protein level in postmortem cerebrospinal fluid
- Hepatobiliary cystadenocarcinoma with rapid growth : report of a case
- Formate Dehydrogenase Gene of Arabidopsis thaliana is Induced by Formaldehyde and Not by Formic Acid
- Magnetostatic Critical Point Phenomena of Single Crystalline Ni
- Successful Preparation of Metabolite of Troglitazone by In-Flow Electrochemical Reaction on Coulometric Electrode
- Histiocytic Necrotizing Lymphadenitis (Kikuchi's Disease) : The Necrotic Appearance of the Lymph Node Cells Is Caused by Apoptosis
- Neurobiological basis of behavioral and psychological symptoms in dementia of the Alzheimer type
- Cis-Trans Isomerization of Proline Dipeptides during Liquid Chromatography : Kinetic Analysis of the Elution Profile
- Elevation of Serum Transaminase Value after Administration of Non-toxic Drugs in Some Volunteers for Phase I Trials: A Study on the Selection of Volunteers.
- Elevated Serum Transaminase Values in Volunteers after Administration of Placebo in a Phase I Study.
- Molecular structure of trimethylphosphine-borane as determined from electron diffraction and microwave spectroscopic data.