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The in vivo monitoring of a concentration changes of biomolecules at a variety f sites of e living systems including blood stream, subcutaneous tissue, muscle, internal organs, and brain, has been desired for the pharmacological, clinical, biological stidis. The most general approach to achieve such goals was the use of implanted biosensors, but it was limited because t variations in sensitivity during the prolonged in vivo monitoring. Recently, icro ili been used as sampling technique for in vivo analysis and i y se, the dialysate to was collected and assayed usually by LC. However, the resolution of e say was not sufficient for real-time monitoring. This article reviews novel flow-injection biosensor systems which make possible n-line real-time monitoring f glucose metabolism and pharmacological behavior of neurotransmitters in brain, etc. This approach was developed y coupling icrodi lysate sampling to a detection system using a flow-inectin interface. The advances i these researches are reviewed together with the results obtained in our recent works.
日本ポーラログラフ学会の論文