Asymmetric hydrogenation of Schiff base prepared from .ALPHA.-keto ester with aliphatic amino acid ester.
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概要
- 論文の詳細を見る
Catalytic hydrogenation of Schiff bases prepared from α-keto esters with amino acid esters was carried out under various conditions. A significant substituent effect of the alkyl group of the ester moiety of amino acid on the stereoselectivity was observed in the hydrogenation of the Schiff bases prepared from methyl pyruvate with (<I>S</I>)-alanine ester. Higher asymmetric yields were obtained as the ester residue of amino acid ester became bulkier. A clear temperature effect on the asymmetric hydrogenation was also observed. These results could be explained by the chelation mechanism.
- 公益社団法人 日本化学会の論文
著者
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Harada Kaoru
Department of Chemistry Faculty of Science Osaka University
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Shiono Shozo
Department of Chemistry, The University of Tsukuba
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