Sterically controlled synthesis of aspartic acid by addition of dialkyl malonate to N-benzyloxycarbonyl-L-alanyl-2-chloroglycine methyl ester.
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概要
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Aspartic acid was synthesized stereoselectively by addition of dialkyl malonate to <I>N</I>-benzyloxycarbonyl-L-alanyl-2-chloroglycine methyl ester, followed by hydrolysis. Substituent effect of the alkyl group of dialkyl malonate on the stereoselectivity was observed. Higher optical purity of aspartic acid was obtained as the alkyl group of dialkyl malonate became bulkier.
- 公益社団法人 日本化学会の論文
著者
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Harada Kaoru
Department of Chemistry Faculty of Science Osaka University
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Shiono Shozo
Department of Chemistry, The University of Tsukuba
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