Chemistry on isoindoles. Novel synthesis of various functionalized isoindoles from 2,3-dicyanobenzaldehyde.
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概要
- 論文の詳細を見る
Various isoindoles having carbonyl, imino, cyano, formyl, and hydroxymethyl groups on the pyrrole or benzene ring were synthesized by new reactions of synthetically versatile 2,3-dicyanobenzaldehyde with a variety of nucleophiles. The obtained isoindoles were further converted to some functionalized isoindoles and phthalazine via recyclization with sodium borohydride and hydrazine. Whereas, <I>N</I>-(2,3-dicyanobenzylidene)anilines, obtained by treating 2,3-dicyanobenzaldehyde with aniline derivatives reacted with elemental sulfur in liquid ammonia or diethylamine to give 7-cyano-2,3-dihydro-3-(4-substituted phenylimino)-1<I>H</I>-isoindole-1-thiones, which were converted into 3-alkylthio-4-cyano-<I>N</I>-(4-substituted phenyl)-1<I>H</I>-isoindol-1-imines by alkylation with alkyl halides in the presence of phase-transfer catalyst.
- 公益社団法人 日本化学会の論文
著者
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Sato Ryu
Department Of Applied Chemistry And Molecular Science Faculty Of Engineering Iwate University
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Saito Minoru
Department Of Agricultural Engineering Faculty Of Agriculture Kagawa University
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Goto Takehiko
Department of Resource Chemistry, Faculty of Engineering, Iwate University
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Abe Akihito
Department of Resource Chemistry, Faculty of Engineering, Iwate University
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Endoh Hidenori
Department of Resource Chemistry, Faculty of Engineering, Iwate University
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Yamaichi Shizuko
Department of Resource Chemistry, Faculty of Engineering, Iwate University
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