Mechanism of Production of Singlet Oxygen on Photoexcitation of Drugs Inducing Photosensitivity.

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概要

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• The mechanism and active species of drug-induced photosensitive reactions were investigated by measuring the absorption spectra of the transient species on photoexcitation as well as by determining the efficiency of singlet oxygen production on quenching by oxygen of the excited state of drugs. The quantum yields of singlet oxygen production were determined for chlorpromazine hydrochloride, mequitazine, and afloqualone as 0.27, 0.28, and 0.14, respectively. These rather high yields of singlet oxygen suggest its important role in photosensitivity of the drugs. On the basis of the transient-spectroscopic investigations the quenching mechanism of excited-state drugs by oxygen was discussed.

• 公益社団法人 日本化学会の論文

著者

• Arai Tatsuo

  Department Of Applied Physics Nagoya University

• Sakuragi Hirochika

  Department Of Chemistry University Of Tsukuba

• Nishimura Yoshinobu

  Department Of Chemical Process Engineering Faculty Of Engineering Hokkaido University

• SASAKI Masako

  Institute of Research and Development, Tokai University

• Matsuo Itsuro

  Tokai Univ. School Of Medicine

• Tokumaru Katsumi

  Department of Chemistry Faculty of Science The University of Tokyo

• Fujita Hitoshi

  Tokai University, School of Medicine

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