Solid Phase Peptide Synthesis by Oxidation-Reduction Condensation. Synthesis of LH–RH by Fragment Condensation on Solid Support
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概要
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Solid phase peptide synthesis by oxidation-reduction condensation was investigated. The fragment condensation on solid support was examined by employing two types of chain elongation, that from <I>C</I>-terminal amino acid to <I>N</I>-terminal amino acid (A type elongation) and that from <I>N</I>-terminal amino acid to <I>C</I>-terminal amino acid (B type elongation). The feasibility of these two approaches A and B was demonstrated in two syntheses of LH–RH (luteinizing hormone-releasing hormone). The LH–RH prepared from the two different chain elongations showed identical mobilities on tlc, exhibiting full activities of natural LH–RH (AVS 77-33 # 215-269).
- 公益社団法人 日本化学会の論文
著者
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Mukaiyama Teruaki
Laboratory of Organic Chemistry Tokyo Institute of Technology
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Takahagi Hidekuni
Product Development Laboratories, Sankyo Co. Ltd.
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Maruyama Hiroshi
Product Development Laboratories, Sankyo Co., Ltd.
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Matsueda Rei
Product Development Laboratories, Sankyo Co., Ltd.
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Kitazawa Eiichi
Product Development Laboratories, Sankyo Co. Ltd.
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Matsueda Rei
Product Development Laboratories, Sankyo Co. Ltd.
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