Solid phase peptide synthesis by oxidation-reduction condensation. Synthesis of adrenocorticotropin(1-24) by chain elongation at the carboxyl end on solid support.

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概要

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• Solid phase peptide synthesis by oxidation-reduction condensation <I>via</I> fragment condensation at the carboxyl end was established by a new monitoring method based on high pressure liquid chromatography. The merit of the method was demonstrated through the synthesis of ACTH (1–24). A resin–tetracosapeptide with quantitative amino acid ratios was easily prepared by coupling 6 fragments of 1–2, 3–7, 8–10, 11–14, 15–19, and 20–24 sequences. ACTH (1–24) with a full activity was obtained in 25% yield from the initial resin-dipeptide by hydrogen fluoride treatment and purification with carboxymethyl-cellulose chromatography.

• 公益社団法人 日本化学会の論文

著者

• Mukaiyama Teruaki

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• Takahagi Hidekuni

  Product Development Laboratories, Sankyo Co., Ltd.

• Takahagi Hidekuni

  Product Development Laboratories, Sankyo Co. Ltd.

• Maruyama Hiroshi

  Product Development Laboratories, Sankyo Co., Ltd.

• Matsueda Rei

  Product Development Laboratories, Sankyo Co., Ltd.

• Kitazawa Eiichi

  Product Development Laboratories, Sankyo Co., Ltd.

• Kitazawa Eiichi

  Product Development Laboratories, Sankyo Co. Ltd.

• Matsueda Rei

  Product Development Laboratories, Sankyo Co. Ltd.

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