NMR study of spontaneous degradation of penicillin G in aqueous solution.
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概要
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The spontaneous degradation of penicillin G in aqueous solution has been studied using NMR and thin layer chromatography. Correlation NMR spectroscopy was used to follow products which appear at the early stage of degradation. It has been found that in 0.3 M phosphate buffer (pH 7.0, 30 °C) a successive first order degradation<BR>penicillin G \xrightarrow<I>k</I><SUB>1</SUB> penicilloic acid \xrightarrow<I>k</I><SUB>2</SUB> secondary product<BR>is dominant with kinetic constants of <I>k</I><SUB>1</SUB>=0.7×10<SUP>−2</SUP> h<SUP>−1</SUP> and <I>k</I><SUB>2</SUB>=6×10<SUP>−2</SUP> h<SUP>−1</SUP>.
- 公益社団法人 日本化学会の論文
著者
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Arata Yoji
Department Of Chemistry Faculty Of Science The University Of Tokyo
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Fujiwara Shizuo
Department Of Chemistry Faculty Of Science Chiba University
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Horiuchi Yoshihiko
School of Medicine, The University of Tokyo
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Mitsumori Fumiyuki
Department of Chemistry, Faculty of Science, The University of Tokyo
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Muranaka Masaharu
School of Medicine, The University of Tokyo
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