白血球細胞内Triiodothyronine (T3) 濃度の測定

概要

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Intracellular T3 concentration in leucocyte was measured by radioimmunoassay following the extraction with the method of Flock et al, (direct method) and compared to the value calculated from the leucocyte/plasma 125I-T3 ratio and plasma T3 concentration (indirect method). T3 in the leucocyte measured by direct method was 680 ng/100g with wider variation and that by indirect method was 275 ng/100g or 0.22 ng/mgDNA with smaller scatter. Considering the technical difficulty inherent to the direct method, the value obtained with indirect method would more closely reflect the intracellular concentration of T3 in leucocytes. The ratio of T3 in leucocyte to plasma was not significantly altered in the patients with overt hyperthyroidism.
日本内分泌学会の論文