慢性甲状腺炎及びグレブス病における酵素組織化学的及び電顕的研究

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The relationship between morphological changes and enzyme activity of the follicular epithelium of the thyroid was studied in five cases of chronic thyroiditis and one of Graves' disease.<BR>In the type of diffuse thyroiditis with oxyphilic epithelium, most oxyphilic cells were negative by peroxidase and acid phosphatase stainings. The epithelial cells in preserved follicles were weakly positive by both stainings. Under electron microscopy the oxyphilic cells showed characteristic cystic dilatation of the endoplasmic reticulum. In diffuse thyroiditis with varied epithelial changes, the results of enzyme histochemistry were various; the oxyphilic cells were negative by both peroxidase and acid phosphatase stainings, whereas the 'small cell nests' were strongly positive by peroxidase stainings, and the cells of hyperplastic follicles were strongly positive by acid phosphatase stainings. Electron microscopical-ly, those cells which are termed here 'small cell nests' contained numerous mitochondria. From these findings the cell kinetics of the follicular epithelium in chronic thyroiditis were speculated as follows : 1) The oxyphilic cells were in a degenerated state and no functional recovery was expected. 2) The small cell nests were regenerating follicles. 3) The hyperplastic epithelium was in an active state, resembling that of a rat's thyroid given TSH.<BR>In one case of Graves' disease treated with anti-thyroid agents for a long period, the results of enzyme histochemistry were also various; the follicular epithelium with papillary proliferation was strongly positive, that with no papillary proliferation was fairly positive, and the cuboidal oxyphilic epithelium with no follicular pattern was negative by both stainings. The latter two epithelial changes were considered to be due to anti-thyroid agents. It was speculated that the cuboidal oxyphilic epithelium in the treated case of Graves' disease was essentially the same as that in the case of chronic thyroiditis from the view point of enzyme histochemistry.
日本内分泌学会の論文

慢性甲状腺炎及びグレブス病における酵素組織化学的及び電顕的研究

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