偽妊娠ウサギ黄体退縮期子宮内膜でのProstaglandin F2α産生調節機構に関する研究

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In previous experiments it was found that PGF2α originating from the uterine endometrium plays a physiologically important role in corpus luteum regression. The present study was undertaken to investigate the regulation of PGF2α release from the uterus in luteolysis. The effect of ovariectomy on PGF2α release was examined. Bilateral ovariectomy was performed on day 14 of pseudopregnancy. PGF2α urinary metabolite excretion was almost constant from day 15 to 22, although a significant increase of PGF2αUM excretion could be seen in the control rabbits. Ovariectomy was performed on day 17. Levels of PGF2αUM excretion increased from day 15 to 17, however, an abrupt decrease occurred after ovariectomy. This indicates that the ovaries are necessary for PGF2α release from the uterus. The effect of steroids on PGF2α release was examined. No significant increase in PGF2αUM excretion could be seen in the ovariectomized pseudopregnant rabbits by the administration of estradiol and/or progesterone, although they are reported to be involved in other species. The effect of the ligation of the vessels between the uterus and ovaries on PGF2α release was investigated. The ligation was performed on day 9. No increase in the production of PGF2α occurred after ligation. Luteal life span was prolonged by 6 days. Endometrial perifusion was carried out to investigate PGF2α production activity on day 18 of the pseudopregnant rabbits after the ligation of the vessels between the uterus and ovaries. PGF2α production activity in the treated rabbits was lower than in the controls. These results indicate that a non-steroidal regulator may regulate PGF2α release via the circulation of the uterus and ovaries in the pseudopregnant rabbit.
日本内分泌学会の論文

偽妊娠ウサギ黄体退縮期子宮内膜でのProstaglandin F<SUB>2</SUB>α産生調節機構に関する研究

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