脳内不活性型レニンの局在および活性化機構に関する研究:第1報 : 正常血圧ラットにおける検討

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Inactive renin in rat brains was investigated according to the following experiments, <BR>1) Treatment with either trypsin or glandular kallikrein of the brain tissue caused a rapid and apparent increase in the renin activity at either 0 or 27°C.<BR>2) The molecular weight of the active renin was estimated to be 40,000 daltons, while that of the trypsin-activatable inactive renin was found to be 48,000 or 61,000 daltons on a column chromatography with Sephadex G-100.<BR>3) The contents of the active renin was the highest in the hypothalamus, followed by striatum, thalamus, midbrain, cerebral cortex, medulla oblongata and cerebellum, while the contents of the trypsin-activatable inactive renin was the highest in the hypothalamus, followed by striatum, thalamus, midbrain, cerebellum, cerebral cortex and medulla oblongata.<BR>4) These results suggest that inactive renin (s) exist in the brain. It seems likely that the brain renin-angiotensin system is modulated by the conversion of inactive to active renin (s),
一般社団法人日本内分泌学会の論文