冠状動脈に狭窄のない病的心筋の糖代謝のメカニズムについて

概要

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The present study was carried out to clarify the mechanism of glucose metabolism in the pathologic myocardium devoid of coronary stenosis, we have used positron CT with use of F-FDG and we have measured quantitatively the amount of the glucose metabolism by Patlak method the following subjects involving 22 patients with cardiomyopathy, 4 patients with pressure-overload hypertrophy, 12 patients with valvular disease. We have discussed the result from the angle of myocardial oxygen consumption, myocardial oxygen supply, and hemodynamics. We can explain this case where glucose mechanism accentuated but devoid of coronary stenosis by the data proposed in this study i. e., the balance of myocardial oxygen consumption and myocardial oxygen supply. With regard to the mitral stenosis it has become undeniable that the case of accentuation of the glucose metabolism is attribution to the vibration of the ventricular wall caused by turbulent blood flow due to mitral stenosis.